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首页> 外文期刊>Journal of neuroendocrinology >The beneficial effects of early short-term exercise in the offspring of obese mothers are accompanied by alterations in the hypothalamic gene expression of appetite regulators and fto (fat mass and obesity associated) gene
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The beneficial effects of early short-term exercise in the offspring of obese mothers are accompanied by alterations in the hypothalamic gene expression of appetite regulators and fto (fat mass and obesity associated) gene

机译：早期短期运动对肥胖母亲的后代的有益影响是伴随着食欲调节剂和fto（肥胖与肥胖相关）基因的下丘脑基因表达的改变

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Maternal overnutrition is implicated in the development of adult metabolic disease, and has been shown to alter the expression of genes involved in energy homeostasis. In the present study, we aimed to test whether a short period of voluntary exercise, followed by a sedentary period, would regulate hypothalamic markers involved in appetite. Adult female Sprague-Dawley rats were fed either normal chow or high-fat diet (HFD) ad lib. for 5 weeks, mated and continued on their assigned diet during gestation/lactation. At weaning males, were separated into chow or HFD groups; half were exercised (running wheels), whereas the remainder were sedentary. At week 10, wheels were removed and rats remained sedentary for 5 weeks, prior to tissue collection. Maternal obesity increased offspring adiposity at 15 weeks and this was exacerbated by postnatal HFD (P < 0.05). Body weight and fat mass were reduced in offspring of obese mothers if they exercised, and this was maintained even after 5 weeks without exercise. At 15 weeks, fasting plasma insulin, leptin and triglyceride concentrations were significantly reduced by exercise in offspring of lean and obese mothers consuming chow, with little benefit in those consuming HFD. Hypothalamic mRNA expression of pro-opiomelanocortin was increased by exercise but only in offspring of lean mothers. Exercise reduced hypothalamic FTO (fat mass and obesity associated) mRNA in offspring of lean dams regardless of diet. A short period of exercise early in life had lasting beneficial effects on body weight, adiposity and hormone profile of male offspring from obese and lean dams, despite being followed by a period of inactivity. The effects of exercise on hypothalamic appetite regulators were more marked in offspring of lean dams.
机译：孕产妇营养不良与成人代谢疾病的发展有关，并且已显示其会改变能量稳态的基因表达。在本研究中，我们旨在测试短时间的自愿运动，然后久坐不动，是否会调节下丘脑标志物与食欲有关。成年雌性Sprague-Dawley大鼠可以随意喂食普通食物或高脂饮食（HFD）。持续5周，在妊娠/哺乳期交配并继续分配饮食。在断奶的雄性中，分为成年组或HFD组;一半的人锻炼（跑轮），其余的久坐。在第10周时，取下轮子，并在收集组织之前让大鼠久坐5周。孕产妇肥胖在15周后会增加后代的肥胖，而产后HFD会加剧肥胖（P <0.05）。肥胖母亲的后代如果运动，体重和脂肪量会减少，即使不运动5周后，体重和脂肪量也能保持。在第15周时，运动和饮食的瘦弱和肥胖母亲的后代运动后，空腹血浆胰岛素，瘦素和甘油三酸酯的浓度显着降低，而那些食用HFD的母亲获益很少。运动引起的前opomelanocortin下丘脑mRNA表达增加，但仅在瘦母亲的后代中增加。无论饮食如何，运动都会使瘦水坝后代的下丘脑FTO（脂肪量和肥胖相关）mRNA降低。在生命的早期进行短暂的运动对肥胖，瘦水坝的雄性后代的体重，肥胖和荷尔蒙特征具有持久的有益影响，尽管其后有一段时间没有运动。在瘦水坝的后代中，运动对下丘脑食欲调节剂的影响更为明显。

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