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首页> 外文期刊>Journal of neuroendocrinology >Y1 receptor activation is involved in the effect of exogenous neuropeptide Y on pup growth and the early termination of lactational diestrus in the postpartum rat.
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Y1 receptor activation is involved in the effect of exogenous neuropeptide Y on pup growth and the early termination of lactational diestrus in the postpartum rat.

机译：Y1受体激活涉及外源性神经肽Y对幼鼠生长和产后大鼠泌乳性分泌早终止的影响。

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摘要

The effect of chronic administration of exogenous neuropeptide Y (NPY) and specific NPY receptor agonists and antagonists on reproductive function was examined in lactating rats. As previously demonstrated in our laboratory, chronic (7-day) intracerebroventricular (i.c.v.) NPY infusion (6 microg/day) from days 8-15 postpartum (pp) caused a significant decrease in milk production and an early termination of lactational diestrus. Similar application of the mixed Y1/Y4/Y5 receptor agonist (Leu31, Pro34) NPY (at 3, 6 and 9 microg/day) reproduced the effect of chronic NPY infusion on milk production in a dose-independent manner. Consistent with this effect, the potent Y1 antagonist/Y4 agonist, 1229U91, given concomitantly with NPY eliminated the decline in milk production. The Y2 receptor agonist, NPY13-36, had no effect on milk production at any of the doses used. Length of lactational diestrus was reduced following administration of the Y2 agonist at 18 microg/day but not at 9 microg or 27 microg/day whereas (Leu31, Pro34) NPY infusion had no effect on this parameter at any of the doses used. However, the group that was treated with NPY plus 1229U91 exhibited the usual length of lactational diestrus, indicating that there is at least some Y1 involvement in the effects of NPY on lactational infertility. To test the possibility that the effects of NPY infusion are mediated through changes in circulating prolactin and progesterone, plasma concentrations of these hormones were measured on day 15 pp in NPY-, (Leu31, Pro34) NPY- and vehicle-treated females. NPY-infused females had lower plasma prolactin concentrations than vehicle-infused dams but progesterone concentrations were similar across groups. Overall, these data indicate that chronic exogenous NPY-infusion in lactating females disrupts milk production and shortens lactational diestrus, most likely through reducing prolactin secretion, and that this effect is mediated via Y1 receptor activity.
机译：在哺乳期大鼠中检查了长期施用外源性神经肽Y（NPY）和特定的NPY受体激动剂和拮抗剂对生殖功能的影响。如我们实验室先前所证明的那样，从产后第8-15天（pp）开始的慢性（7天）脑室内（i.c.v.）NPY输注（6 microg /天）导致牛奶产量显着下降和泌乳性早泄的早期终止。混合Y1 / Y4 / Y5受体激动剂（Leu31，Pro34）NPY（3、6和9微克/天）的类似应用以剂量独立的方式再现了长期NPY输注对牛奶生产的影响。与这种作用一致，与NPY并用的强效Y1拮抗剂/ Y4激动剂1229U91消除了牛奶产量的下降。 Y2受体激动剂NPY13-36在任何剂量下均不影响产奶量。在以18微克/天的剂量施用Y2激动剂后，泌乳性二头肌的长度减少了，但以9微克/ 27微克/天的剂量施用却没有，而（Leu31，Pro34）NPY输注在任何剂量下均对该参数无影响。但是，接受NPY加1229U91治疗的组表现出正常的泌乳性发情长度，表明NPY对泌乳性不育的影响中至少有一些Y1参与。为了测试通过循环泌乳素和孕酮的变化介导NPY输注的可能性，在NPY-，（Leu31，Pro34）NPY-和媒介物治疗的雌性中，在第15天测量这些激素的血浆浓度。 NPY注入的雌性血浆催乳素浓度低于溶媒注入的母鼠，但各组的孕酮浓度相似。总的来说，这些数据表明，哺乳期女性长期慢性外源性NPY输注会中断乳汁生产并缩短泌乳期的母乳，这很可能是通过减少催乳激素分泌来实现的，并且这种作用是通过Y1受体活性来介导的。

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