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首页> 外文期刊>Journal of neuroendocrinology >Altered Hippocampal White Matter Connectivity in Type 2 Diabetes Mellitus and Memory Decrements
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Altered Hippocampal White Matter Connectivity in Type 2 Diabetes Mellitus and Memory Decrements

机译：2型糖尿病患者海马白质连接性改变和记忆减退

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摘要

Type 2 diabetes mellitus is associated with cognitive decrements. Specifically affected cognitive domains are learning and memory, for which the hippocampus plays an essential role. The pathophysiological mechanism remains to be revealed. The present study examined whether local hippocampal microstructure and white matter connectivity are related to type 2 diabetes and memory performance. Forty participants with type 2 diabetes and 38 participants without type 2 diabetes underwent detailed cognitive assessment and 3-Tesla diffusion magnetic resonance imaging (MRI). Diffusion MRI was performed to assess microstructure (fractional anisotropy and mean diffusivity) and white matter connectivity (tract volume) of the hippocampus, which were compared between participants with and without type 2 diabetes. No differences in hippocampal microstructure were observed. Participants with type 2 diabetes had fewer white matter connections between the hippocampus and frontal lobe (P=0.017). Participants who scored lower on memory function, regardless of type 2 diabetes, had fewer white matter connections between the hippocampus and temporal lobe (P=0.017). Taken together, type 2 diabetes and memory decrements appear to be associated with altered hippocampal white matter connectivity.
机译：2型糖尿病与认知能力下降有关。受到特别影响的认知领域是学习和记忆，海马对此起着至关重要的作用。病理生理机制仍有待揭示。本研究检查了局部海马微结构和白质连通性是否与2型糖尿病和记忆功能有关。对40位2型糖尿病参与者和38位非2型糖尿病参与者进行了详细的认知评估和3-Tesla扩散磁共振成像（MRI）。进行了弥散MRI，以评估海马的微观结构（分数各向异性和平均扩散率）和白质连通性（束体积），并在有和没有2型糖尿病的参与者之间进行了比较。没有观察到海马微结构的差异。患有2型糖尿病的参与者海马与额叶之间的白质连接较少（P = 0.017）。不论2型糖尿病如何，记忆功能评分较低的参与者海马与颞叶之间的白质联系较少（P = 0.017）。两者合计，2型糖尿病和记忆力减退似乎与海马白质连通性改变有关。

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