SEQUENTIALLY FOLDED SV-11 RNA - METASTABILITY IS RELEVANT TO BIOLOGICAL FUNCTION

Fernandez A.; Belinky A.

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SEQUENTIALLY FOLDED SV-11 RNA - METASTABILITY IS RELEVANT TO BIOLOGICAL FUNCTION

机译：顺序折叠的SV-11 RNA-转移性与生物学功能有关

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By simulating a Markov process comprising kinetically controlled elementary chain-growth steps and upstream refolding events, we compute the sequential folding of SV-11 RNA; a species capable of acting as a template instructing its own replication when folded into a metastable conformation. The predicted structure is endowed with available primers for replication and is identical within the regions of homology to the experimentally probed active structure of MNV-11 RNA, a species from which SV-11 RNA has evolved. The uneven rate of chain growth during SV-11 RNA replication and the pause sites along the replica sequence are determined. Such predictions are testable in pulse-chase kinetic experiments. [References: 7]

机译：通过模拟一个包括动力学控制的基本链增长步骤和上游重折叠事件的马尔可夫过程，我们计算了SV-11 RNA的顺序折叠。当折叠成亚稳构象时，能够充当模板指示其自身复制的物种。预测的结构被赋予可用的引物用于复制，并且在与MNV-11 RNA的实验探测的活性结构的同源性区域内相同，MNV-11 RNA是从中进化出SV-11 RNA的物种。确定了SV-11 RNA复制过程中链增长的不均匀速率以及沿着复制序列的暂停位点。这种预测在脉冲追逐动力学实验中是可检验的。 [参考：7]

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《Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena》 |1996年第3期|共5页
作者
Fernandez A.; Belinky A.;
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原文格式 PDF
正文语种 eng
中图分类生物化学;生物物理学;
关键词
Rna sequential folding; Recombinant rna; Q-beta replicase; Computer simulations; Elongation; Chain;

机译：Rna顺序折叠;重组RNA;Q-β复制酶;计算机模拟;延伸率;链;

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1. SEQUENTIALLY FOLDED SV-11 RNA - METASTABILITY IS RELEVANT TO BIOLOGICAL FUNCTION [J] . Fernandez A., Belinky A. Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 1996,第2a3期

机译：顺序折叠的SV-11 RNA-转移性与生物学功能有关
2. Sequential barriers and an obligatory metastable intermediate define the apparent two-state folding pathway of the ubiquitin-like PB1 domain of NBR1. [J] . Chen P, Long J, Searle MS Journal of Molecular Biology . 2008,第5期

机译：顺序屏障和强制性的亚稳中间体定义了NBR1泛素样PB1域的明显的两态折叠途径。
3. Finding Protein Targets for Small Biologically Relevant Ligands across Fold Space Using Inverse Ligand Binding Predictions [J] . Gang Hu, Jianzhao Gao, Kui Wang, Structure . 2012,第11期

机译：使用逆配体结合预测在折叠空间中寻找与生物相关的小配体的蛋白质靶标
4. Comparing RNA Structures with Biologically Relevant Operations Cannot Be Done without Strong Combinatorial Restrictions [C] . Guillaume Blin, Sylvie Hamel, Stephane Vialette WALCOM: algorithms and computation . 2010

机译：没有强大的组合限制就无法完成具有生物学相关操作的RNA结构比较
5. Creating a three-dimensional fold and biological function in a non-biological polymer. [D] . Lee, Byoung-Chul. 2006

机译：在非生物聚合物中创建三维折叠和生物功能。
6. Formation of metastable RNA structures by sequential folding during transcription: time-resolved structural analysis of potato spindle tuber viroid (-)-stranded RNA by temperature-gradient gel electrophoresis. [O] . D Repsilber, S Wiese, M Rachen, 1999

机译：通过转录过程中顺序折叠形成亚稳态RNA结构：通过温度梯度凝胶电泳对马铃薯纺锤形块茎类病毒（-）链RNA进行时间分辨的结构分析。
7. Formation of metastable RNA structures by sequential folding during transcription: time-resolved structural analysis of potato spindle tuber viroid (-)-stranded RNA by temperature-gradient gel electrophoresis. [O] . Repsilber, D, Wiese, S, Rachen, M, 1999

机译：通过转录过程中顺序折叠形成亚稳态RNA结构：通过温度梯度凝胶电泳对马铃薯纺锤形块茎类病毒（-）链RNA进行时间分辨的结构分析。

SEQUENTIALLY FOLDED SV-11 RNA - METASTABILITY IS RELEVANT TO BIOLOGICAL FUNCTION

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