首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation (published erratum appears in J Neuroimmunol 1999 Feb 1;94(1-2):222)
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A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation (published erratum appears in J Neuroimmunol 1999 Feb 1;94(1-2):222)

机译:通过靶向差异显示鉴定的新型大鼠CC趋化因子在脑炎症中被上调(发表的勘误出现在J Neuroimmunol 1999 Feb 1; 94(1-2):222)

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摘要

A novel rat chemokine, termed ST38, was identified through its upregulation in ischemic brain tissue using a biased differential display technique targeting mRNAs with regulatory AUUUA-motifs typically found in transcripts of cytokine and immediate early genes. ST38 transcripts were transiently induced in ischemic cortex between 4 and 24 h after middle cerebral artery occlusion. ST38 is a member of the CC chemokine family, closely related to human Exodus-1. The gene of the mouse ST38 homologue was mapped to the central region of chromosome 1. In experimental autoimmune panencephalomyelitis ST38 expression correlated with the onset of inflammation and was significantly reduced by TNF-neutralization in vivo. Inflammatory stimuli induce ST38 transcription in astrocyte, microglia and macrophage cultures. These findings suggest a role of ST38 in the control of neuroinflammatory tissue responses.
机译:一种新型的大鼠趋化因子称为ST38,是通过使用一种偏向差异显示技术将其在缺血性脑组织中的上调而鉴定出来的,该偏向展示技术以通常在细胞因子和立即早期基因的转录本中发现的具有调节性AUUUA基序的mRNA为目标。在大脑中动脉闭塞后4到24小时之间,在缺血皮层中短暂诱导出ST38转录物。 ST38是CC趋化因子家族的成员,与人类Exodus-1密切相关。小鼠ST38同源基因的基因定位在1号染色体的中央区域。在实验性自身免疫性全脑脊髓炎中,ST38的表达与炎症的发生有关,并且在体内被TNF中和后显着降低。炎性刺激在星形胶质细胞,小胶质细胞和巨噬细胞培养物中诱导ST38转录。这些发现表明ST38在控制神经炎症组织反应中的作用。

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