首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Vasoactive intestinal peptide inhibits IL-12 and nitric oxide production in murine macrophages.
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Vasoactive intestinal peptide inhibits IL-12 and nitric oxide production in murine macrophages.

机译:血管活性肠肽抑制鼠巨噬细胞中IL-12和一氧化氮的产生。

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摘要

Vasoactive intestinal peptide (VIP) is a naturally occurring neuropeptide widely distributed in the nervous system. In this study, we investigated the effect of VIP on IL-12, TNF alpha and nitric oxide (NO) production in macrophages following activation with lipopolysaccharide (LPS) or superantigens. In vitro studies show that at physiologic concentrations, VIP inhibited IL-12 and NO but not TNF alpha production in macrophages which were stimulated with LPS or superantigens. The inhibitory effect of VIP on IL-12 production appeared to be cAMP mediated since other cAMP inducing agents were also potent in inhibiting IL-12 production. Since IL-12 plays a critical role in T cell function, we suggest that naturally occurring neural hormones can regulate the type and direction of the immune response.
机译:血管活性肠肽(VIP)是一种广泛存在于神经系统中的天然神经肽。在这项研究中,我们调查了脂多糖(LPS)或超抗原激活后VIP对巨噬细胞中IL-12,TNFα和一氧化氮(NO)产生的影响。体外研究表明,在生理浓度下,VIP抑制巨噬细胞中IL-12和NO的IL-12和NO的生成,但抑制LPS或超抗原刺激的巨噬细胞中TNFα的生成。 VIP对IL-12产生的抑制作用似乎是cAMP介导的,因为其他cAMP诱导剂也有效抑制IL-12的产生。由于IL-12在T细胞功能中起关键作用,因此我们建议自然发生的神经激素可以调节免疫反应的类型和方向。

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