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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus).
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Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus).

机译：mar猴（Callithrix jacchus）在急性EAE中辅助分子和细胞因子的表达。

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Accessory molecules and cytokines are involved in the immunopathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) in rodent models, and are potential targets for immunotherapy. Evaluation of such experimental therapies requires appropriate animal models. Therefore, we analysed the expression of selected accessory molecules and cytokines in the brain of marmoset monkeys (Callithrix jacchus) with acute EAE, a newly described non-human primate model for MS. All animals experienced active disease clinically and histopathologically with strong resemblance to MS. Perivascular infiltrates of mononuclear cells showed abundant expression of CD40. CD40 was expressed on macrophages, indicating that T cell priming and macrophage effector functions may result from local CD40-CD40L interactions. CD40 ligand (CD40L) and B7-2 (CD86) were also expressed, but to a lower extent, while B7-1 (CD80) expression was limited. Both pro-inflammatory and anti-inflammatory cytokines were produced within individual lesions during active disease (IFN-alpha, IFN-gamma, TNF-alpha, IL-1alpha, IL-1beta, IL-2, IL-4, IL-10 and IL-12). This suggests that relative levels rather than sequential expression of Th1- and Th2-type cytokines determine disease activity. These findings demonstrate the value of EAE in marmoset monkeys as a model to assess the role of accessory molecules and cytokines in multiple sclerosis, and to evaluate targeted intervention.
机译：在啮齿动物模型中，辅助分子和细胞因子参与了多发性硬化症（MS）和实验性自身免疫性脑脊髓炎（EAE）的免疫发病机制，并且是免疫治疗的潜在目标。对此类实验疗法的评估需要适当的动物模型。因此，我们分析了具有急性EAE（一种新近描述的MS非人类灵长类动物模型）的mar猴（Callithrix jacchus）的大脑中所选辅助分子和细胞因子的表达。所有动物均在临床和组织病理学上经历过活动性疾病，与MS极为相似。单核细胞的血管周围浸润显示CD40大量表达。 CD40在巨噬细胞上表达，表明T细胞启动和巨噬细胞效应子功能可能是由于局部CD40-CD40L相互作用引起的。还表达了CD40配体（CD40L）和B7-2（CD86），但程度较低，而B7-1（CD80）表达受到限制。在活动性疾病（IFN-α，IFN-γ，TNF-alpha，IL-1alpha，IL-1beta，IL-2，IL-4，IL-10和IL-12）。这表明Th1和Th2型细胞因子的相对水平而非顺序表达决定了疾病的活动。这些发现表明，EAE在mar猴中的价值可作为评估辅助分子和细胞因子在多发性硬化症中的作用以及评估靶向干预的模型。

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