• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Evidence for opioid receptors on cells involved in host defense and the immune system.
【24h】

Evidence for opioid receptors on cells involved in host defense and the immune system.

机译：参与宿主防御和免疫系统的细胞上阿片样物质受体的证据。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although the role of opiates and opioids in the physiological and pathological function of the immune system is only beginning to be unraveled, converging lines of evidence indicate that the opioid receptors expressed by immune cells are often the same or similar to the neuronal subtypes, particularly delta and kappa. Recent studies also point to the existence of novel opioid receptors and/or binding sites on immune cells that are selective for morphine. Opioids and their receptors, particularly those with high affinity for delta agonists, appear to function in an autocrine/paracrine manner. Thus, opioid peptides generated from immune-derived proenkephalin A act as cytokines, capable of regulating myriad functions of both granulocytes and mononuclear cells. Further identification and characterization of receptors and signal transduction pathways that account for some of the unique properties of opiate binding and immunomodulation (e.g., dose-dependent effects of morphine that occur at exceptionally low concentrations relative to the Kd's of the neuronal mu receptor or the morphine binding site reported on activated human T-cells) represents one of the major research challenges ahead. Elucidating mechanisms, such as these, may provide unique therapeutic opportunities through the application of opioid immunopharmacology to disorders involving immune responses in peripheral organs and the central nervous system.
机译：尽管鸦片和阿片类药物在免疫系统的生理和病理功能中的作用才刚刚被弄清楚，但越来越多的证据表明，免疫细胞表达的阿片类药物受体通常与神经元亚型（尤其是δ）相同或相似。和卡帕最近的研究还指出了对吗啡具有选择性的免疫细胞上存在新型阿片受体和/或结合位点。阿片类药物及其受体，特别是对δ激动剂具有高亲和力的受体，似乎以自分泌/旁分泌方式起作用。因此，由免疫衍生的前脑啡肽A产生的阿片样物质肽充当细胞因子，能够调节粒细胞和单核细胞的无数功能。受体和信号转导途径的进一步鉴定和表征，它们解释了鸦片结合和免疫调节的某些独特特性（例如，吗啡的剂量依赖性效应发生在相对于神经元mu受体或吗啡的Kd极低的浓度下在激活的人类T细胞上报道的结合位点）是未来的主要研究挑战之一。通过将阿片类药物免疫药理学应用于涉及周围器官和中枢神经系统免疫应答的疾病，诸如此类的阐明机制可能提供独特的治疗机会。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号