• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Optic neuritis in chronic relapsing experimental allergic encephalomyelitis in Biozzi ABH mice: demyelination and fast axonal transport changes in disease.
【24h】

Optic neuritis in chronic relapsing experimental allergic encephalomyelitis in Biozzi ABH mice: demyelination and fast axonal transport changes in disease.

机译：Biozzi ABH小鼠的慢性复发性实验性过敏性脑脊髓炎中的视神经炎：疾病中的脱髓鞘和快速轴突运输变化。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The encephalitogenicity of optic nerve tissue was demonstrated in Biozzi ABH (H-2(dq1)) mice. Acute experimental allergic encephalomyelitis (EAE) occurred in 11/14 animals and 4/5 exhibited relapse. The involvement of the optic nerve in spinal cord homogenate induced chronic relapsing EAE (CREAE) was demonstrated by mononuclear cell infiltration and myelin degradation in the optic nerve prior to and during clinical disease. During the relapse phase gross pathological assessment revealed swollen and translucent plaques on the optic nerves. Advanced lesions showed widespread demyelination, astrocytic gliosis and fibrotic changes of the blood vessels. Physiologically, the fast axonal transport of proteins from the retina to the optic nerve and superior colliculus was significantly decreased during relapse. The association of inflammation and demyelination with physiological deficit in the optic nerve highlights the usefulness of this model in the study of multiple sclerosis in which acute monosymptomatic unilateral optic neuritis is a common manifestation. Furthermore, the novel induction of CREAE with optic nerve homogenate suggests that optic neuritis is a common significant role in the pathophysiology and progression of neurological disease in CREAE which may be relevant to studies of optic neuritis in multiple sclerosis.
机译：在Biozzi ABH（H-2（dq1））小鼠中证明了视神经组织的脑致病性。急性实验性过敏性脑脊髓炎（EAE）发生在11/14只动物中，有4/5复发。在临床疾病之前和期间，视神经中单核细胞浸润和髓磷脂降解证明了视神经参与脊髓匀浆诱导的慢性复发性EAE（CREAE）。在复发阶段，总体病理评估显示视神经肿胀和半透明的斑块。晚期病变表现为广泛的脱髓鞘，星形胶质细胞胶质增生和血管纤维化改变。在生理上，在复发期间，蛋白质从视网膜到视神经和上丘的快速轴突转运明显减少。炎症和脱髓鞘与视神经生理缺陷的相关性突显了该模型在多发性硬化症研究中的有用性，在多发性硬化症中，急性单症状性单侧视神经炎是常见表现。此外，视神经匀浆对CREAE的新颖诱导表明，视神经炎在CREAE的病理生理和神经系统疾病进展中具有普遍的重要作用，这可能与多发性硬化症中视神经炎的研究有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号