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Brain mast cells lack the c-kit receptor: immunocytochemical evidence.

机译:脑肥大细胞缺乏c-kit受体:免疫细胞化学证据。

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摘要

Mast cells are reported to differ from other cells of the hematopoietic lineage in that as mature cells, they retain the c-kit receptor, and are thus capable of responding to the stem cell factor (SCF) ligand. SCF is important for development and survival of mast cells. In this study, c-kit expression was examined immunocytochemically in the brains of mice, rats and doves. The results indicate that brain mast cells lack the c-kit receptor; those of the leptomeninges and other connective tissues are a mixed population of c-kit positive and negative cells. The mechanisms whereby brain mast cells might survive in the absence of SCF-c-kit signaling are discussed.
机译:据报道肥大细胞与造血谱系的其他细胞不同,因为肥大细胞作为成熟细胞保留了c-kit受体,因此能够对干细胞因子(SCF)配体作出反应。 SCF对于肥大细胞的发育和存活很重要。在这项研究中,对小鼠,大鼠和鸽子的大脑中的c-kit表达进行了免疫细胞化学检查。结果表明脑肥大细胞缺乏c-kit受体。轻薄组织和其他结缔组织的那些是c-kit阳性和阴性细胞的混合群体。讨论了在没有SCF-c-kit信号的情况下脑肥大细胞可能存活的机制。

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