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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Human immunodeficiency virus glycoproteins 160 and 41 alter sleep and brain temperature of rats.
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Human immunodeficiency virus glycoproteins 160 and 41 alter sleep and brain temperature of rats.

机译：人类免疫缺陷病毒糖蛋白160和41会改变大鼠的睡眠和脑温。

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摘要

Sleep is altered during all stages at which it has been recorded during chronic human immunodeficiency virus (HIV) infection, including the long latent phase before the development of AIDS; the mechanisms for such alterations are not known. The HIV envelope glycoprotein (gp) 120 alters sleep of rats in a manner somewhat similar to the alterations that occur in humans infected with HIV. To further determine which components of the virus may be responsible for altered behavior, we administered centrally into rats prior to dark onset recombinant HIV gp160 or gp41. Both glycoproteins increased non-rapid eye movements sleep, fragmented sleep, altered slow frequency components of the electroencephalogram, and induced modest febrile responses. These results complement and extend those previously obtained after gp120; HIV envelope glycoproteins are capable of altering sleep.
机译：在慢性人类免疫缺陷病毒（HIV）感染期间记录的所有阶段，睡眠都发生改变，包括在艾滋病发生之前的长期潜伏期。这种改变的机制尚不清楚。 HIV包膜糖蛋白（gp）120以某种类似于在感染HIV的人类中发生的改变的方式改变大鼠的睡眠。为了进一步确定病毒的哪些成分可能与行为改变有关，我们在黑暗发作的重组HIV gp160或gp41之前对大鼠进行了集中给药。两种糖蛋白均增加了非快速眼动睡眠，破碎的睡眠，改变了脑电图的低频成分以及诱发了适度的发热反应。这些结果补充并扩展了先前在gp120之后获得的结果; HIV包膜糖蛋白能够改变睡眠。

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