The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages.

Van Muiswinkel-FL; Raupp SF; de Vos-NM; Smits HA; Verhoef J; Eikelenboom P; Nottet HS

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages.

【24h】

The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages.

机译：淀粉样β蛋白的氨基末端对于细胞结合以及随后激活人类巨噬细胞的呼吸爆发至关重要。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Here, we show that amyloid-beta (Abeta) is capable to prime and activate the respiratory burst of human macrophages. Previously, the N-terminus of Abeta(1-42) has been shown to contain a cell binding domain that is implicated in eliciting neuropathogenic microglia in vitro. To evaluate the role of this domain in the Abeta(1-42)-induced respiratory burst activity, the effect of Abeta subfragments on the Abeta(1-42)-induced superoxide release were studied. On the basis of the antagonistic properties of Abeta(1-16), it is concluded that the N-terminal region of Abeta is critical for the cellular binding and consequent activation of the respiratory burst of human phagocytes.

机译：在这里，我们显示淀粉样蛋白-β（Abeta）能够引发和激活人类巨噬细胞的呼吸爆发。以前，已显示Abeta（1-42）的N端包含一个细胞结合域，该域与体外诱发神经致病性小胶质细胞有关。若要评估此域在Abeta（1-42）诱导的呼吸爆发活性中的作用，研究了Abeta亚片段对Abeta（1-42）诱导的超氧化物释放的影响。根据Abeta（1-16）的拮抗特性，可以得出结论，Abeta的N端区域对于细胞结合以及随后激活人类吞噬细胞的呼吸爆发至关重要。

著录项

来源
《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |1999年第1期|共10页
作者
Van Muiswinkel-FL; Raupp SF; de Vos-NM; Smits HA; Verhoef J; Eikelenboom P; Nottet HS;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
关键词
Amyloid beta-Protein; Macrophages; Peptide Fragments; Respiratory Burst; 淀粉样β蛋白; 巨噬细胞; 肽碎片; 呼吸爆发;

机译：Amyloid beta-Protein;Macrophages;Peptide Fragments;Respiratory Burst;淀粉样β蛋白;巨噬细胞;肽碎片;呼吸爆发;

相似文献

外文文献
中文文献
专利

1. The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages. [J] . Van Muiswinkel-FL, Raupp SF, de Vos-NM, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 1999,第1期

机译：淀粉样β蛋白的氨基末端对于细胞结合以及随后激活人类巨噬细胞的呼吸爆发至关重要。
2. Activation of neutrophil respiratory burst by fungal particles requires phosphatidylinositol 3-phosphate binding to p40 phox in humans but not in mice [J] . BagaitkarJ., MatuteJ.D., AustinA., Blood: The Journal of the American Society of Hematology . 2012,第16期

机译：真菌颗粒激活嗜中性粒细胞呼吸爆发需要在人类中而不是小鼠中将磷脂酰肌醇3-磷酸结合至p40 phox
3. Identification of cellular proteins that interact with Newcastle Disease Virus and human Respiratory Syncytial Virus by a two-dimensional virus overlay protein binding assay (VOPBA) [J] . Javier Holguera, Enrique Villar, Isabel Munoz-Barroso Virus Research: An International Journal of Molecular and Cellular Virology . 2014,第Null期

机译：通过二维病毒覆盖蛋白结合测定（VOPBA）鉴定与新城疫病毒和人类呼吸道合胞病毒相互作用的细胞蛋白
4. Human p2-Glycoprotein I Binds To Endothelial Cells Through A Cluster of Lysihe Residues that Are Critical for Anionic Phospholipid Binding and Offers Epitopes for Anti- p2-Glycoprotein I Antibodies [C] . Del Papa N, Sheng YH, Raschi E, NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：人P2-糖蛋白I通过对阴离子磷脂结合至关重要的Lysihe残基团结合内皮细胞，并为抗P2-糖蛋白I抗体提供表位
5. Pulmonary surfactant protein A interactions with human macrophages: Binding and trafficking of SP-A, and alteration of the respiratory burst. [D] . Crowther, Joy Elizabeth. 2005

机译：肺表面活性蛋白A与人类巨噬细胞的相互作用：SP-A的结合和运输，以及呼吸爆发的改变。
6. Lipopolysaccharide-Binding Protein- and CD14-Dependent Activation of Mitogen-Activated Protein Kinase p38 by Lipopolysaccharide in Human Neutrophils Is Associated with Priming of Respiratory Burst [O] . Sen Rong Yan, Walla Al-Hertani, David Byers, 2002

机译：脂多糖结合蛋白和CD14依赖的脂多糖在人类嗜中性粒细胞中的丝裂原活化蛋白激酶p38的激活与呼吸爆发的引发有关。
7. Lipopolysaccharide-Binding Protein- and CD14-Dependent Activation of Mitogen-Activated Protein Kinase p38 by Lipopolysaccharide in Human Neutrophils Is Associated with Priming of Respiratory Burst [O] . Yan, Sen Rong, Al-Hertani, Walla, Byers, David, 2002

机译：脂多糖结合蛋白和CD14依赖的脂多糖在人类嗜中性粒细胞中的丝裂原活化蛋白激酶p38的激活与呼吸爆发的引发有关。

The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages.

摘要

著录项

相似文献

相关主题

期刊订阅