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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Interleukin-10 (IL10) promoter polymorphisms and multiple sclerosis.
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Interleukin-10 (IL10) promoter polymorphisms and multiple sclerosis.

机译：白介素10（IL10）启动子多态性和多发性硬化症。

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摘要

Interleukin-10 (IL10) is an anti-inflammatory cytokine which may modulate disease expression in multiple sclerosis (MS). Three dimorphic polymorphisms within the IL10 promoter region at positions - 1082, -819 and -519 have previously been identified. The - 1082*A allele has been associated with low and the - 1082*G allele with high in vitro IL10 production. We have genotyped 185 Caucasian MS patients and 211 ethnically matched controls for each of these three dimorphisms. MS patients were stratified for severity of disease outcome. No associations were found for any IL10 promoter polymorphisms when the MS cases were compared with controls or with disease outcome with regards to disability. IL10 polymorphism does not appear to be associated with MS or to influence disease progression.
机译：白细胞介素10（IL10）是一种抗炎细胞因子，可调节多发性硬化症（MS）中的疾病表达。先前已经鉴定出IL10启动子区域内在位置-1082，-819和-519的三个双态多态性。 -1082 * A等位基因与体外IL10产生量低相关，-1082 * G等位基因与体外IL10产生量相关。对于这三种二态性，我们已分别对185名白种人MS患者和211名种族匹配的对照进行了基因分型。 MS患者根据疾病预后的严重程度进行分层。将MS病例与对照或与残疾相关的疾病结果进行比较时，未发现任何IL10启动子多态性的关联。 IL10多态性似乎与MS无关，也不影响疾病进展。

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