Expression of MHC class I heavy chain and beta2-microglobulin in rat brainstem motoneurons and nigral dopaminergic neurons.

Linda H; Hammarberg H; Piehl F; Khademi M; Olsson T

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Expression of MHC class I heavy chain and beta2-microglobulin in rat brainstem motoneurons and nigral dopaminergic neurons.

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Expression of MHC class I heavy chain and beta2-microglobulin in rat brainstem motoneurons and nigral dopaminergic neurons.

机译：MHC I类重链和β2-微球蛋白在大鼠脑干运动神经元和黑色素多巴胺能神经元中的表达。

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We demonstrate here that motoneurons and nigral dopaminergic neurons in the brainstem of the adult rat, with the exception of motoneurons innervating ocular muscles, display high levels of both MHC class I heavy chain and beta2-microglobulin mRNAs. These neurons also display interferon-gamma receptor mRNA. We find it striking that these particular neurons are those which are vulnerable to neurodegeneration in diseases such as Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS).

机译：我们在这里证明成年大鼠脑干中的运动神经元和黑色素多巴胺能神经元，除神经运动神经支配于眼部肌肉外，均显示高水平的MHC I类重链和β2-微球蛋白mRNA。这些神经元还显示干扰素-γ受体mRNA。我们发现令人惊讶的是，这些特定的神经元是那些在帕金森氏病（PD）和肌萎缩性侧索硬化症（ALS）等疾病中容易发生神经退行性变的神经元。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |1999年第1期|共11页
作者
Linda H; Hammarberg H; Piehl F; Khademi M; Olsson T;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
关键词
beta 2-Microglobulin; Brain Stem; Histocompatibility Antigens Class I; Motor Neurons; β2微球蛋白; 脑干; 组织相容性抗原Ⅰ类; 运动神经元; 黑质;

机译：beta 2-Microglobulin;Brain Stem;Histocompatibility Antigens Class I;Motor Neurons;β2微球蛋白;脑干;组织相容性抗原Ⅰ类;运动神经元;黑质;

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1. Expression of MHC class I heavy chain and beta2-microglobulin in rat brainstem motoneurons and nigral dopaminergic neurons. [J] . Linda H, Hammarberg H, Piehl F, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 1999,第1期

机译：MHC I类重链和β2-微球蛋白在大鼠脑干运动神经元和黑色素多巴胺能神经元中的表达。
2. Expression of MHC class I and beta2-microglobulin in rat spinal motoneurons: regulatory influences by IFN-gamma and axotomy. [J] . Linda H, Hammarberg H, Cullheim S, Experimental Neurology . 1998,第2期

机译：MHC I类和beta2-微球蛋白在大鼠脊髓运动神经元中的表达：IFN-γ和轴突切开术的调节作用。
3. Differential association of beta2-microglobulin mutants with MHC class I heavy chains and structural analysis demonstrate allele-specific interactions. [J] . Shields MJ, Hodgson W, Ribaudo RK Molecular Immunology . 1999,第9期

机译：β2-微球蛋白突变体与MHC I类重链的差异关联和结构分析表明等位基因特异性相互作用。
4. TAP expression level in tumor cells defines the nature and processing of MHC class I peptides for recognition by tumor-specific cytotoxic T lymphocytes [C] . Faten El Hage, Aurélie Durgeau, Fathia Mami-Chouaib Federation of Immunological Societies of Asia-Oceania. . 2013

机译：肿瘤细胞中的敲击表达水平定义了MHC类I肽的性质和加工，用于通过肿瘤特异性细胞毒性T淋巴细胞识别
5. Expression of HLA class I heavy chain and TcR gamma-chain homologs in human cytomegalovirus-infected human cells [D] . Mostello, Elizabeth Antonia 1998

机译：HLA I类重链和TcRγ链同源物在人巨细胞病毒感染的人细胞中的表达
6. Overexpression of MHC Class I Heavy Chain Protein in Young Skeletal Muscle Leads to Severe Myositis [O] . Charles Kwok-chong Li, Paul Knopp, Halima Moncrieffe, 2009

机译：MHC I类重链蛋白在年轻骨骼肌中的过表达导致严重的肌炎
7. Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. [O] . Eric J Benner, Rebecca Banerjee, Ashley D Reynolds, 2008

机译：硝化的α-突触核蛋白免疫加速黑质多巴胺能神经元的退化。
8. Reduction of 3-Methoxytyramine Concentrations in the Caudate Nucleus of Rats After Exposure to High-Energy Iron Particles: Evidence for Deficits in Dopaminergic Neurons. [R] . Hunt, W. A., Dalton, T. K., Joseph, J. A., 1990

机译：暴露于高能铁粒子后大鼠尾状核中3-甲氧基酪胺浓度的降低：多巴胺能神经元缺陷的证据。

Expression of MHC class I heavy chain and beta2-microglobulin in rat brainstem motoneurons and nigral dopaminergic neurons.

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