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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Leukocyte adhesion molecule expression and T cell naive/memory status following isoproterenol infusion.
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Leukocyte adhesion molecule expression and T cell naive/memory status following isoproterenol infusion.

机译：异丙肾上腺素输注后白细胞粘附分子表达和T细胞幼稚/记忆状态。

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摘要

This study examined adhesion molecules on peripheral leukocytes following a 30-min infusion of the beta-adrenergic agonist isoproterenol in 23 healthy subjects. In response to isoproterenol, the number of CD8 +CD62L- T cells and both CD62L+ and CD62L-natural killer (NK) (CD3 CD16+ 56+) cells increased markedly in circulation (p < 0.001). In addition, the surface density of CD62L was significantly lower on both CD8+ and CD4+ T cells (p < 0.001). Plasma levels of soluble CD62L remained unchanged, arguing against an isoproterenol-induced shedding of L-selectin. In contrast to CD62L, the surface density of the beta2 integrin LFA-1 (CD11a) was higher on circulating lymphocytes (p < 0.001) (but not monocytes or lymphocytes) post-infusion. Isoproterenol also led to a mobilization of memory/activated CD8+CD29high T cells (p < 0.01), but had no significant effect on the number of circulating CD8+ CD45RA+ CD62L+ naive T cells. beta blockade with the non-specific antagonist propranolol eliminated these isoproterenol-induced effects.
机译：这项研究在23位健康受试者中注入了30分钟的β-肾上腺素能激动剂异丙肾上腺素后，检查了外周白细胞上的粘附分子。响应异丙肾上腺素，循环中CD8 + CD62L- T细胞以及CD62L +和CD62L-自然杀手（NK）（CD3 CD16 + 56+）细胞的数量均显着增加（p <0.001）。此外，CD8 +和CD4 + T细胞上CD62L的表面密度均显着降低（p <0.001）。血浆可溶性CD62L水平保持不变，这与异丙肾上腺素诱导的L-选择蛋白脱落有关。与CD62L相反，输注后循环淋巴细胞（p <0.001）（而非单核细胞或淋巴细胞）的beta2整合素LFA-1（CD11a）的表面密度更高。异丙肾上腺素也导致记忆/激活的CD8 + CD29high T细胞动员（p <0.01），但对循环CD8 + CD45RA + CD62L +幼稚T细胞的数量没有显着影响。使用非特异性拮抗剂普萘洛尔的β受体阻滞剂消除了异丙肾上腺素诱导的这些作用。

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