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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Glia-T cell dialogue.
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Glia-T cell dialogue.

机译：胶质-T细胞对话。

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摘要

Interactions of CD4(+) T helper (Th) cells with microglia and astrocytes are likely to play an important role in regulating immune responses as well as tissue damage and repair during infectious and autoimmune central nervous system (CNS) diseases. T cells secreting Th1-type cytokines provide inducing signals for microglia to mature into functional antigen presenting cells (APC). The ability of microglia to act as efficient APC for the restimulation of Th1 cells suggests a role for these cells in the local amplification of pro-inflammatory immune responses. Conversely, the Th2-inducing capacity of microglia and astrocytes together with their ability to produce anti-inflammatory mediators could play a role in providing counter-regulatory signals limiting CNS inflammation. In this article, we review recent studies addressing the functional significance of T cell-CNS glia interactions and present new data on the expression of cyclooxygenase-2, the inducible enzyme involved in prostanoid biosynthesis, in microglia and astrocytes during the course of experimental allergic encephalomyelitis.
机译：CD4（+）T辅助（Th）细胞与小胶质细胞和星形胶质细胞的相互作用很可能在传染性和自身免疫性中枢神经系统（CNS）疾病的调节免疫反应以及组织损伤和修复中起重要作用。分泌Th1型细胞因子的T细胞为小胶质细胞提供诱导信号，使其成熟为功能性抗原呈递细胞（APC）。小胶质细胞充当有效的APC来重新刺激Th1细胞的能力暗示了这些细胞在促炎性免疫反应的局部扩增中的作用。相反，小胶质细胞和星形胶质细胞的Th2诱导能力及其产生抗炎介质的能力可能在提供限制CNS炎症的反调节信号中发挥作用。在本文中，我们回顾了有关T细胞-CNS神经胶质细胞相互作用的功能性研究的最新研究，并提供了在实验性变应性脑脊髓炎过程中小胶质细胞和星形胶质细胞中环氧合酶-2（前列腺素生物合成中涉及的可诱导酶）的表达的新数据。 。

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