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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: imbalance of Th1/Th2-associated chemokine signaling.
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Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: imbalance of Th1/Th2-associated chemokine signaling.

机译：多发性硬化症复发和缓解时血液和脑脊液中T细胞上趋化因子受体的表达：Th1 / Th2相关趋化因子信号的失衡。

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摘要

The expression of chemokine receptors on lymphocytes in the blood and CSF of multiple sclerosis (MS) patients was analyzed at relapse and remission. Both CD4+ and CD8+ cells in CSF at relapse were enriched for Th1-type receptors CXCR3 and CCR5 expression, and were reduced for Th2-type receptors CCR3 and CCR4 expression compared with those of the blood. CCR1 and CCR2 expressions on T cells were increased in CSF and blood, respectively. At remission, CCR5 expression, but not CXCR3 expression, was reduced in CSF CD4+ cells. A biased Th1/Th2 balance may play a critical role in active inflammation and CCR5 on CSF CD4+ cells is a good marker of the disease activity.
机译：在复发和缓解时，分析多发性硬化症（MS）患者血液和CSF中淋巴细胞上趋化因子受体的表达。与血液相比，复发时CSF中的CD4 +和CD8 +细胞均富集Th1型受体CXCR3和CCR5表达，而Th2型受体CCR3和CCR4表达降低。 T细胞中的CCR1和CCR2表达在CSF和血液中分别升高。缓解后，CSF CD4 +细胞中的CCR5表达降低，但CXCR3表达降低。有偏见的Th1 / Th2平衡可能在活跃的炎症中起关键作用，而CSF CD4 +细胞上的CCR5是疾病活动的良好标志。

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