Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages.

Chiarugi A; Calvani M; Meli E; Traggiai E; Moroni F

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages.

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Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages.

机译：人单核细胞衍生的巨噬细胞合成和释放神经毒性犬尿氨酸代谢产物。

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We studied the regulation of the kynurenine pathway of tryptophan metabolism in human monocyte-derived macrophages (MDM) with the aim of evaluating macrophage involvement in inflammatory neurological disorders.Cultured MDM metabolized tryptophan and released kynurenine metabolites, including the excitotoxin quinolinic acid (QUIN). Lipopolysaccharides (LPS) or the pro-inflammatory cytokines INFgamma and TNFalpha increased, while IL 4 or IL 10 inhibited the rate of tryptophan metabolism and the release of QUIN.The incubation media of INFgamma-exposed MDM caused neuronal death in primary cultures of mixed cortical cells. Glutamate receptor antagonists or poly(ADP-ribose) polymerase inhibitors significantly reduced this death, thus suggesting new possibilities for the treatment of neuronal damage in neuroinflammatory disorders.

机译：我们研究了人单核细胞衍生巨噬细胞（MDM）中色氨酸的犬尿氨酸途径的调节作用，旨在评估巨噬细胞是否参与炎性神经系统疾病。脂多糖（LPS）或促炎细胞因子INFgamma和TNFalpha升高，而IL 4或IL 10抑制色氨酸代谢率和QUIN的释放。细胞。谷氨酸受体拮抗剂或聚（ADP-核糖）聚合酶抑制剂显着降低了这种死亡，从而为治疗神经炎性疾病中的神经元损伤提供了新的可能性。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2001年第2期|共9页
作者
Chiarugi A; Calvani M; Meli E; Traggiai E; Moroni F;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
关键词
Cytokines; Encephalitis; Kynurenine; Macrophages; Monocytes; Neurons; Tryptophan; 细胞活素类; 脑炎; 犬尿氨酸; 巨噬细胞; 单核细胞; 神经元; 色氨酸;

机译：Cytokines;Encephalitis;Kynurenine;Macrophages;Monocytes;Neurons;Tryptophan;细胞活素类;脑炎;犬尿氨酸;巨噬细胞;单核细胞;神经元;色氨酸;

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1. Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages. [J] . Chiarugi A, Calvani M, Meli E, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2001,第1a2期

机译：人单核细胞衍生的巨噬细胞合成和释放神经毒性犬尿氨酸代谢产物。
2. Differences in kinetics of human cytomegalovirus cell-free viral release after in vitro infection of human microglial cells, astrocytes and monocyte-derived macrophages. [J] . Lecointe D, Hery C, Janabi N, Journal of neurovirology . 1999,第3期

机译：在人小胶质细胞，星形胶质细胞和单核细胞衍生的巨噬细胞体外感染后，人类巨细胞病毒无细胞病毒释放动力学的差异。
3. Moraxella catarrhalis stimulates the release of proinflammatory cytokines and prostaglandin E from human respiratory epithelial cells and monocyte-derived macrophages. [J] . Fink J, Mathaba LT, Stewart GA, FEMS immunology and medical microbiology . 2006,第2期

机译：卡他莫拉菌刺激人呼吸道上皮细胞和单核细胞衍生的巨噬细胞释放促炎细胞因子和前列腺素E。
4. Progress toward the validation of liquid chromatography - tandem mass spectrometry-based methods for the quantitative determination of key kynurenine pathway metabolites in human plasma and cerebrospinal fluid [C] . Mike Allen, Ben Begley, David Delinsky, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：液相色谱 - 串联质谱法定量测定人血浆和脑脊液中关键寿命途径代谢产物的验证研究进展
5. Investigation of human immune deficiency virus type I mechanisms of immune escape during infection of monocyte-derived macrophages. [D] . Kadiu, Irena. 2008

机译：研究人类免疫缺陷病毒I型感染单核细胞衍生的巨噬细胞期间的免疫逃逸机制。
6. Substance P augments tumor necrosis factor release in human monocyte-derived macrophages. [O] . H R Lee, W Z Ho, S D Douglas 1994

机译：P物质可增强人类单核细胞衍生巨噬细胞中的肿瘤坏死因子释放。
7. Figure 7: Effect of PQQ4R, CPZ and PAβN on LDH release from human monocyte-derived macrophages. [O] . -1

机译：图7：PQQ4R，CPZ和PAβN对人单核细胞衍生巨噬细胞LDH释放的影响。

Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages.

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