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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation.
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Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation.

机译：在缺氧/低血糖和随后的复氧作用下，白藜芦醇抑制皮质混合神经胶质细胞中白细胞介素6的产生。

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摘要

Reactive oxygen intermediates (ROIs) are important mediators of a variety of pathological processes, including inflammation and ischemia/reperfusion injury. Cytokines and chemokines are detected at mRNA level in human and animal ischemic brains. This suggests that hypoxia/reoxygenation may induce cytokine production through generation of ROIs. In this study, we investigated the cytokine induction and inhibition by antioxidants in rat cortical mixed glial cells exposed to in vitro ischemia-like insults (hypoxia plus glucose deprivation). The results showed that interleukin-6 (IL-6) mRNA and protein, but not tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), were induced during hypoxia/hypoglycemia followed by reoxygenation in the mixed glial cells. The accumulation of IL-6 mRNA was induced as early as 15 min after hypoxia/hypoglycemia and its level was further increased after subsequent reoxygenation. Among the antioxidants studied, only resveratrol suppressed IL-6 gene expression and protein secretion in mixed glial cultures under hypoxia/hypoglycemia followed by reoxygenation. These findings suggest that resveratrol might be useful in treating ischemic-induced inflammatory processes in stroke.
机译：活性氧中间体（ROIs）是多种病理过程的重要介体，包括炎症和局部缺血/再灌注损伤。在人和动物局部缺血的脑中，在mRNA水平检测到细胞因子和趋化因子。这表明缺氧/复氧可能通过产生ROIs诱导细胞因子的产生。在这项研究中，我们研究了暴露于体外缺血样损伤（缺氧加葡萄糖剥夺）的大鼠皮质混合神经胶质细胞中抗氧化剂对细胞因子的诱导和抑制作用。结果表明，在低氧/低血糖症患者中诱导了白细胞介素6（IL-6）mRNA和蛋白，但未诱导肿瘤坏死因子-α（TNF-alpha）或白细胞介素-1β（IL-1beta），然后在混合液中复氧胶质细胞。早在低氧/低血糖症发生后15分钟就诱导了IL-6 mRNA的积累，在随后的复氧后其水平进一步升高。在研究的抗氧化剂中，在低氧/低血糖症后再充氧的情况下，只有白藜芦醇抑制了混合神经胶质细胞培养物中的IL-6基因表达和蛋白质分泌。这些发现表明白藜芦醇可能在治疗缺血性中风引起的炎症过程中有用。

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