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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis.
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Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis.

机译：聚（ADP-核糖）合成酶激活在实验性变应性脑脊髓炎的发展中的作用。

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摘要

Peroxynitrite formation has been demonstrated during experimental allergic encephalomyelitis (EAE). Furthermore, peroxynitrite has been identified as an activator of poly(ADP-ribose) synthetase (PARS), an enzyme implicated in neurotoxicity. In the current study, we examined the role of PARS activation in the development of EAE. Administration of the PARS inhibitor 5-iodo-6-amino-1,2-benzopyrone (INH2BP) delayed the onset of EAE and reduced the incidence and severity of disease signs. Moreover, drug treatment lowered iNOS activity and decreased cell infiltration in cervical spinal tissues from EAE-sensitized animals. To conclude, the results of the present investigation suggest that PARS activity may contribute to the pathogenesis of EAE.
机译：实验性变应性脑脊髓炎（EAE）期间已证明过亚硝酸盐的形成。此外，过氧亚硝酸盐已被鉴定为聚（ADP-核糖）合成酶（PARS）的活化剂，该酶与神经毒性有关。在当前的研究中，我们检查了PARS激活在EAE发展中的作用。 PARS抑制剂5-碘-6-氨基-1,2-苯并吡喃酮（INH2BP）的给药延迟了EAE的发作，并降低了疾病征象的发生率和严重程度。此外，药物治疗降低了来自EAE敏感动物的颈脊髓组织中的iNOS活性并减少了细胞浸润。总而言之，本研究的结果表明，PARS活性可能与EAE的发病机理有关。

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