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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Enhanced susceptibility to Theiler's virus-induced demyelinating disease in perforin-deficient mice.
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Enhanced susceptibility to Theiler's virus-induced demyelinating disease in perforin-deficient mice.

机译：穿孔素缺乏症小鼠对泰勒病毒引起的脱髓鞘疾病的敏感性增强。

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摘要

Theiler's virus induces immune-mediated demyelinating disease similar to human MS in susceptible mice. Though the MHC class II-restricted T cell response is critical, susceptibility/resistance is also associated with a MHC class I haplotype. Here we report that perforin-deficient C57BL/6 mice (pKO) are susceptible to demyelination and develop clinical disease. The levels of primary demyelination, proliferation, Th1 responses, and viral load were also markedly enhanced. In addition, immunization of pKO mice with UV-inactivated virus further enhanced clinical incidence and accelerated the disease course. Thus, perforin is most likely involved in viral clearance, hence protection from the disease.
机译：泰勒病毒在易感小鼠中诱发类似于人MS的免疫介导的脱髓鞘疾病。尽管限制MHC II类的T细胞反应很关键，但易感性/耐药性也与MHC I类单倍型有关。在这里，我们报告穿孔素缺陷型C57BL / 6小鼠（pKO）易于脱髓鞘并发展为临床疾病。原发性脱髓鞘，增殖，Th1反应和病毒载量的水平也显着提高。此外，用紫外线灭活的病毒对pKO小鼠进行免疫可进一步提高临床发病率并加速疾病进程。因此，穿孔素最有可能参与病毒清除，因此可以预防该疾病。

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