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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells.
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Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells.

机译：MS患者出现活跃的MRI病变之前，循环T辅助1和2细胞会出现波动。

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BACKGROUND: The role of T cell subpopulations and their ability to produce immunoregulatory cytokines has been extensively studied in multiple sclerosis (MS). However, the exact mechanisms by which T cells and cytokines contribute to disease activity remain to be clarified. OBJECTIVES: To analyze the longitudinal relation between markers of T cell activation and differentiation and disease activity in MS patients. METHODS: During a period of 9 months, clinical disease activity was scored, monthly MRI scans were performed, and blood was taken for immune measurements in a group of 13 untreated clinically definite MS patients. RESULTS: Disease activity, as measured by the occurrence of active MRI lesions, is associated with a significant transient decrease in both T cells producing interferon-gamma (IFN-gamma) and T cells producing interleukin (IL)-4. CONCLUSIONS: Our results suggest that MRI-documented disease activity is associated with a transient decrease in circulating cytokine producing T cells, possibly due to the migration of activated T cells into the CNS.
机译：背景：在多发性硬化症（MS）中，已经广泛研究了T细胞亚群的作用及其产生免疫调节细胞因子的能力。但是，T细胞和细胞因子促成疾病活动的确切机制仍有待阐明。目的：分析MS患者T细胞活化和分化标志物与疾病活动的纵向关系。方法：在9个月的时间里，对13名未经治疗的临床确诊MS患者进行了评分，对临床疾病活动进行了评分，每月进行了MRI扫描，并抽取了血液进行免疫测量。结果：通过活动性MRI病变的发生来衡量疾病活动，与产生干扰素-γ（IFN-γ）的T细胞和产生白介素（IL）-4的T细胞的明显瞬时减少有关。结论：我们的结果表明，MRI记录的疾病活动与循环产生细胞因子的T细胞的短暂减少有关，这可能是由于活化的T细胞向中枢神经系统迁移所致。

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