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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Monoclonal antibody against human glioblastoma multiforme (U-87MG) immunoprecipitates a protein of molecular mass 38 kDa and inhibits tumor growth in nude mice.
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Monoclonal antibody against human glioblastoma multiforme (U-87MG) immunoprecipitates a protein of molecular mass 38 kDa and inhibits tumor growth in nude mice.

机译：抗人胶质母细胞瘤的单克隆抗体（U-87MG）免疫沉淀分子量为38 kDa的蛋白质，并抑制裸鼠中的肿瘤生长。

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摘要

A monoclonal antibody 6DS1 against a human glioblastoma multiforme cell line U-87MG recognizes a tumor-specific, cell surface antigen of human glioblastoma cell lines. Partial cross-reactivity is observed with two human neuroblastoma cell lines, SK-N-SH and SK-N-MC, with little or no reactivity towards a rat glioma cell line C6 or normal human adult and fetal brain tissues. The antibody recognizes an antigen of molecular mass 38 kDa as inferred from Western blot analysis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the immunoprecipitate. The monoclonal antibody 6DS1 inhibits both the attachment to substratum and growth of U-87MG cells. It strongly cross-reacts with xenotransplants of U-87MG cells and inhibits tumorigenesis (subcutaneous implants of U-87MG cells) in nude mice.
机译：针对人胶质母细胞瘤多形细胞系U-87MG的单克隆抗体6DS1识别人胶质母细胞瘤细胞系的肿瘤特异性细胞表面抗原。在两种人类神经母细胞瘤细胞系SK-N-SH和SK-N-MC中观察到部分交叉反应，对大鼠神经胶质瘤细胞系C6或正常人成年和胎儿脑组织几乎没有反应。该抗体识别免疫沉淀的蛋白质印迹分析和十二烷基硫酸钠-聚丙烯酰胺凝胶电泳所推断的分子量为38 kDa的抗原。单克隆抗体6DS1抑制U-87MG细胞与基质的附着和生长。它与U-87MG细胞的异种移植物发生强烈的交叉反应，并抑制裸鼠的肿瘤发生（U-87MG细胞的皮下植入物）。

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