• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Suppression of cell-transferred experimental autoimmune encephalomyelitis in defibrinated Lewis rats.
【24h】

Suppression of cell-transferred experimental autoimmune encephalomyelitis in defibrinated Lewis rats.

机译：去纤维化的Lewis大鼠中细胞转移性实验性自身免疫性脑脊髓炎的抑制。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The role of coagulation-fibrinolysis system in experimental autoimmune encephalomyelitis (EAE) was studied by using batroxobin, derived from the venom of the South American pit viper Bothrops atrox moojeni. Batroxobin converts circulating fibrinogen into an insoluble form and causes a profound degree of afibrinogenemia. Batroxobin treatment (30 BU/kg/day) suppressed clinical signs of cell transferred EAE; the mean cumulative clinical score for batroxobin treated rats was 3.97, while saline treated controls scored 6.9 (P < 0.01). Plasma fibrinogen concentration decreased significantly in batroxobin-treated rats. Histologically, the degree of perivascular mononuclear cell infiltration in the spinal cord was not suppressed in batroxobin-treated rats compared to saline-treated control rats, however, deposition of fibrin around the vessels in the spinal cord was markedly suppressed in batroxobin-treated rats. These findings suggest that batroxobin suppresses EAE by preventing fibrin deposition, and provide evidence that CNS-associated deposition of fibrin and ensuing fibrinolysis, together with increased permeability of blood brain barrier (BBB), are related prerequisites for the clinical manifestation of EAE.
机译：凝血-纤维蛋白溶解系统在实验性自身免疫性脑脊髓炎（EAE）中的作用是通过使用巴曲酶（batroxobin）研究的，巴曲酶来源于南美蛇毒蛇Bothrops atrox moojeni的毒液。巴曲酶将循环的纤维蛋白原转化为不溶形式，并引起严重的纤维蛋白原血症。巴曲酶治疗（30 BU / kg /天）抑制了细胞转移EAE的临床体征;巴曲酶治疗的大鼠的平均累积临床平均得分为3.97，而盐水治疗的对照组的平均得分为6.9（P <0.01）。巴曲酶治疗的大鼠血浆纤维蛋白原浓度显着降低。组织学上，与盐水对照组大鼠相比，巴曲酶治疗的大鼠脊髓周围血管单个核细胞的浸润程度没有受到抑制，但是，巴曲酶治疗的大鼠中脊髓周围血管周围的纤维蛋白沉积明显受到抑制。这些发现表明，巴曲酶通过防止纤维蛋白沉积抑制EAE，并提供证据表明CNS相关的纤维蛋白沉积和随后的纤维蛋白溶解以及血脑屏障（BBB）通透性增加是EAE临床表现的相关先决条件。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号