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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Expression of functional chemokine receptors by rat cerebellar neurons.
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Expression of functional chemokine receptors by rat cerebellar neurons.

机译：大鼠小脑神经元表达功能性趋化因子受体。

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摘要

In this study, we examined chemokine receptor expression and function in rat cerebellar neurons. Calcium imaging experiments demonstrated that a wide variety of chemokines elicited [Ca(2+)](i) transients in acutely isolated and cultured cerebellar Purkinje and granule neurons. In many cases, these chemokine responses were pertussis toxin (PTX) insensitive. In addition, chemokines activated the Ca(2+) and cAMP-dependent transcription factor CREB and the extracellular response kinases ERK1/ERK2. Chemokines increased the survival of Purkinje neurons deprived of their trophic support. Thus, the presence of chemokine receptors and the signaling pathways they activate suggest that chemokines play a role in the control of cerebellar neuron survival and development and may mediate communication between the CNS and the immune system.
机译：在这项研究中，我们检查了大鼠小脑神经元中趋化因子受体的表达和功能。钙成像实验表明，多种趋化因子在急性分离和培养的小脑浦肯野和颗粒神经元中诱发了[Ca（2 +）]（i）瞬变。在许多情况下，这些趋化因子反应对百日咳毒素（PTX）不敏感。此外，趋化因子激活Ca（2+）和依赖cAMP的转录因子CREB和细胞外应答激酶ERK1 / ERK2。趋化因子增加了缺乏营养支持的浦肯野神经元的存活。因此，趋化因子受体的存在及其激活的信号通路表明，趋化因子在控制小脑神经元的存活和发育中发挥作用，并可能介导CNS与免疫系统之间的通讯。

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