Linear B-cell epitopes in Lambert-Eaton myasthenic syndrome defined by cell-free synthetic peptide binding.

Parsons KT; Kwok WW

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Linear B-cell epitopes in Lambert-Eaton myasthenic syndrome defined by cell-free synthetic peptide binding.

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Linear B-cell epitopes in Lambert-Eaton myasthenic syndrome defined by cell-free synthetic peptide binding.

机译：兰伯特-伊顿肌无力综合征中的线性B细胞表位，由无细胞合成肽结合定义。

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Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare autoimmune disorder characterized by autoantibodies that bind to P/Q voltage-gated calcium channels at the neuromuscular junction. Using cell-free direct peptide binding in 12 LEMS patients, we find linear B-cell epitopes that reside on the extracellular peptide linkers between the S5-S6 transmembrane peptides of Domains II and IV. A major epitope is located within the S5-S6 linker peptide of Domain IV defined by the acidic amino acid sequence EDEDSDEDE.

机译：Lambert-Eaton重症肌无力综合症（LEMS）是一种罕见的自身免疫性疾病，其特征是自身抗体与神经肌肉接头处的P / Q电压门控钙通道结合。使用无细胞直接肽结合在12名LEMS患者中，我们发现线性B细胞表位位于结构域II和IV的S5-S6跨膜肽之间的细胞外肽连接子上。主要表位位于由酸性氨基酸序列EDEDSDEDE定义的域IV的S5-S6接头肽内。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2002年第2期|共6页
作者
Parsons KT; Kwok WW;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
关键词
Peptides; binding; Lambert-Eaton Myasthenic Syndrome; Cells; B-Lymphocytes; 肽类; 郎伯综合征; 细胞; B淋巴细胞;

机译：Peptides;binding;Lambert-Eaton Myasthenic Syndrome;Cells;B-Lymphocytes;肽类;郎伯综合征;细胞;B淋巴细胞;

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1. Linear B-cell epitopes in Lambert-Eaton myasthenic syndrome defined by cell-free synthetic peptide binding. [J] . Parsons KT, Kwok WW Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2002,第1a2期

机译：兰伯特-伊顿肌无力综合征中的线性B细胞表位，由无细胞合成肽结合定义。
2. Immunogenicity of synthetic peptide constructs based on PvMSP9(E795-A808), a linear B-cell epitope of the P. vivax Merozoite Surface Protein-9 [J] . Rodrigues-da-Silva Rodrigo Nunes, Correa-Moreira Daniely, Soares Isabela Ferreira, Vaccine . 2019,第2期

机译：基于PVMSP9（E795-A808）的合成肽构建体的免疫原性，P.Vivax Merozoite表面蛋白-9的线性B细胞表位-9
3. Potential application of small myristoylated protein-3 evaluated as recombinant antigen and a synthetic peptide containing its linear B-cell epitope for the serodiagnosis of canine visceral and human tegumentary leishmaniasis [J] . Salles Beatriz C. S., Dias Daniel S., Steiner Bethina T., Immunobiology: Zeitschrift fur Immunitatsforschung . 2019,第1期

机译：小型肌肉蛋白-3的潜在应用作为重组抗原和含有其线性B细胞表位的合成肽，用于犬内脏和人Tegumenary LeishManiaisis的血型诊断
4. Modular B-cell and T-cell Epitope Assembly in a Peptide-based Vaccine [C] . Rebecca R. Pompano, Jianjun Chen, Emily A. Verbus, Society for Biomaterials annual meeting and exposition . 2013

机译：基于肽的疫苗中的模块化B细胞和T细胞表位组装
5. Peptide-based B-cell epitope vaccines targeting HER-2/neu. [D] . Garrett, Joan T. 2007

机译：靶向HER-2 / neu的基于肽的B细胞表位疫苗。
6. Improving Serodiagnosis of Human and Canine Leishmaniasis with Recombinant Leishmania braziliensis Cathepsin L-like Protein and a Synthetic Peptide Containing Its Linear B-cell Epitope [O] . Daniel Menezes-Souza, Tiago Antônio de Oliveira Mendes, Matheus de Souza Gomes, 2015

机译：重组巴西利什曼原虫组织蛋白酶L样蛋白和包含其线性B细胞表位的合成肽改善人和犬利什曼病的血清学诊断
7. Vaccine engineering: enhancement of immunogenicity of synthetic peptide vaccines related to hepatitis in chemically defined models consisting of T- and B-cell epitopes. [O] . Tam, J P, Lu, Y A 1989

机译：疫苗工程：在由T细胞和B细胞表位组成的化学定义模型中，增强与肝炎有关的合成肽疫苗的免疫原性。

Linear B-cell epitopes in Lambert-Eaton myasthenic syndrome defined by cell-free synthetic peptide binding.

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