Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system.

Sorensen TL; Trebst C; Kivisakk P; Klaege KL; Majmudar A; Ravid R; Lassmann H; Olsen DB; Strieter RM; Ransohoff RM; Sellebjerg F

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system.

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Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system.

机译：多发性硬化症：CXCL10和CXCR3在发炎的中枢神经系统中共定位的研究。

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T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.

机译：T细胞在中枢神经系统（CNS）中的积累被认为对多发性硬化症（MS）的发病机制至关重要。我们发现脑脊液（CSF）隔室内的大多数T细胞表达CXC趋化因子受体3（CXCR），独立于中枢神经系统炎症。定量免疫组化显示MS病变形成过程中CXCR3 + T细胞不断积累。一种CXCR3配体，干扰素（IFN）-γ诱导型10 kDa（IP-10）/ CXC趋化因子配体（CXCL）10的表达在MS CSF中升高，在空间上与CNS组织切片中的脱髓鞘相关，并与CXCR3表达。这些数据表明CXCL10和CXCR3在MS患者中枢神经系统中T细胞积累中起着关键作用。

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来源
《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2002年第2期|共10页
作者
Sorensen TL; Trebst C; Kivisakk P; Klaege KL; Majmudar A; Ravid R; Lassmann H; Olsen DB; Strieter RM; Ransohoff RM; Sellebjerg F;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
关键词
Central Nervous System; Morphine Sulfate; T-Lymphocytes; seconds; CXC chemokine IP-10; 中枢神经系统; T淋巴细胞;

机译：Central Nervous System;Morphine Sulfate;T-Lymphocytes;seconds;CXC chemokine IP-10;中枢神经系统;T淋巴细胞;

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1. Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system. [J] . Sorensen TL, Trebst C, Kivisakk P, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2002,第1a2期

机译：多发性硬化症：CXCL10和CXCR3在发炎的中枢神经系统中共定位的研究。
2. CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. [J] . Christensen JE, de Lemos C, Moos T, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2006,第7期

机译：CXCL10是CD8 +效应T细胞上CXCR3的关键配体，参与了淋巴细胞性脉络膜脑膜炎病毒感染的中枢神经系统的免疫监视。
3. The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and nonmyeloid cells in inflamed human central nervous system: analysis in multiple sclerosis and bacterial meningitis. [J] . Gasque P, Singhrao SK, Neal JW, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1998,第7期

机译：补体过敏毒素C3a的受体在发炎的人中枢神经系统中由髓样细胞和非髓样细胞表达：在多发性硬化症和细菌性脑膜炎中的分析。
4. Optimalization Of NMR Micro Imaging (1.9T, 4.7T, 7.4T) Of The Central Nervous System Of An Animal Model For Multiple Sclerosis [C] . Donimisse R., Lanens D., Spanoghe M., Engineering in Medicine and Biology Society, 1991. Vol.13: 1991., Proceedings of the Annual International Conference of the IEEE . 1991

机译：多发性硬化症动物模型中枢神经系统NMR微成像（1.9T，4.7T，7.4T）的优化
5. Interleukin-15 and NKG2 receptors modulate CD8 T cell responses in the central nervous system during multiple sclerosis. [D] . Saikali, Philippe. 2009

机译：白细胞介素15和NKG2受体在多发性硬化期间调节中枢神经系统中的CD8 T细胞反应。
6. Characterization of IM virus which is frequently isolated from cerebrospinal fluid of patients with multiple sclerosis and other chronic diseases of the central nervous system. [O] . J L Melnick, S S Wang, E Seidel, 1984

机译：IM病毒的特征通常从患有多发性硬化症和其他中枢神经系统慢性疾病的患者的脑脊液中分离出来。
7. Effects of exercise training on multiple sclerosis biomarkers of central nervous system and disease status: a systematic review of intervention studies [O] . R. Negaresh, R. W. Motl, P. Zimmer, 2019

机译：运动训练对中枢神经系统多发性硬化生物标志物的影响：干预研究的系统综述
8. Organic Solvents and the Central Nervous System. Chronic Effects of Organic Solvents on the Central Nervous System and Diagnostic Criteria [R] . 1985

机译：有机溶剂和中枢神经系统。有机溶剂对中枢神经系统的慢性影响及诊断标准

Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system.

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