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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Abrupt or precipitated withdrawal from morphine induces immunosuppression.
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Abrupt or precipitated withdrawal from morphine induces immunosuppression.

机译：从吗啡突然或沉淀的撤药会诱导免疫抑制。

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摘要

The present studies tested the effect of withdrawal from morphine by two different paradigms, abrupt withdrawal (AW) or precipitated withdrawal (PW), on the capacity of murine spleen cells to mount an in vitro antibody response. Mice were made dependent by chronic treatment using s.c. implanted morphine slow-release pellets. Splenocytes were harvested at various time points after withdrawal and the number of antibody-forming cells determined using a plaque-forming cell (PFC) assay. The results indicate that induction of abstinence from morphine in dependent mice by either paradigm caused marked immunosuppression between 24 and 48 h post-withdrawal. However, the kinetics of onset and recovery from immunosuppression were different in AW and PW.
机译：本研究测试了通过两种不同的模式从吗啡戒断，即突然戒断（AW）或沉淀戒断（PW）对鼠脾细胞进行体外抗体应答的能力的影响。通过使用s.c.植入吗啡缓释微丸。停药后的各个时间点收获脾细胞，并使用噬斑形成细胞（PFC）测定法确定抗体形成细胞的数量。结果表明，任一范例在依赖小鼠中诱导吗啡戒断，均在戒断后24至48小时内引起明显的免疫抑制。但是，AW和PW的起效和免疫抑制恢复动力学是不同的。

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