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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Induction of macrophage-derived chemokine/CCL22 expression in experimental autoimmune encephalomyelitis and cultured microglia: implications for disease regulation.
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Induction of macrophage-derived chemokine/CCL22 expression in experimental autoimmune encephalomyelitis and cultured microglia: implications for disease regulation.

机译：在实验性自身免疫性脑脊髓炎和培养的小胶质细胞中诱导巨噬细胞衍生的趋化因子/ CCL22表达：对疾病调节的影响。

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摘要

Macrophage-derived chemokine (MDC/CCL22) and its receptor CCR4 have been implicated in chronic inflammatory processes and in the homing of monocytes, Th2 cells and regulatory T-cell subsets. Here, we demonstrate that MDC and CCR4 mRNAs are expressed in the central nervous system (CNS) of mice developing relapsing-remitting and chronic-relapsing forms of experimental autoimmune encephalomyelitis (EAE). By immunohistochemistry, we show that MDC is produced by CNS-infiltrating leukocytes and intraparenchymal microglia, whereas CCR4 is expressed on some invading leukocytes. Upon in vitro activation, mouse microglia express MDC transcripts and secrete bioactive MDC that induces chemotaxis of Th2, but not Th1 cells. We suggest that MDC produced by microglia could regulate Th1-mediated CNS inflammation by facilitating the homing of Th2 and, possibly, regulatory T cells into the lesion site.
机译：巨噬细胞衍生的趋化因子（MDC / CCL22）及其受体CCR4与慢性炎症过程以及单核细胞，Th2细胞和调节性T细胞亚群的归巢有关。在这里，我们证明MDC和CCR4 mRNA在小鼠中枢神经系统（CNS）中表达，后者发展为实验性自身免疫性脑脊髓炎（EAE）的复发-缓解和慢性复发形式。通过免疫组织化学，我们显示MDC是由中枢神经系统浸润的白细胞和实质内小胶质细胞产生的，而CCR4在某些侵入的白细胞上表达。在体外激活后，小鼠小胶质细胞表达MDC转录本，并分泌可诱导Th2细胞趋化性但不诱导Th1细胞趋化性的生物活性MDC。我们建议，由小胶质细胞产生的MDC可以通过促进Th2的归巢和可能的调节性T细胞进入病变部位来调节Th1介导的CNS炎症。

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