• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Role of IL-5 during primary and secondary immune response to acetylcholine receptor.
【24h】

Role of IL-5 during primary and secondary immune response to acetylcholine receptor.

机译：IL-5在对乙酰胆碱受体的初次和二次免疫反应中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To analyze the role of the Th2 cytokine interleukin-5 (IL-5) in experimental autoimmune myasthenia gravis (EAMG) pathogenesis, we induced clinical EAMG in C57BL/6 and IL-5 gene-knockout (KO) mice in the C57BL/6 background. IL-5 KO mice had a significantly reduced incidence and severity of EAMG. Despite their increased resistance to EAMG, IL-5 KO mice displayed intact secondary antibody and lymphoproliferative responses to acetylcholine receptor (AChR) after immunization with this molecule. However, the relative resistance of IL-5 KO mice was associated with a reduced primary lymphocyte response to AChR, and reduced C3 levels in muscle extracts compared to those in C57BL/6 mice.
机译：为了分析Th2细胞因子白介素5（IL-5）在实验性自身免疫性重症肌无力（EAMG）发病机理中的作用，我们在C57BL / 6中的C57BL / 6和IL-5基因敲除（KO）小鼠中诱导了临床EAMG背景。 IL-5 KO小鼠的EAMG发生率和严重程度明显降低。尽管它们对EAMG的抵抗力增强，但用该分子免疫后，IL-5 KO小鼠仍表现出完整的二抗和对乙酰胆碱受体（AChR）的淋巴增生反应。然而，与C57BL / 6小鼠相比，IL-5 KO小鼠的相对抗性与对AChR的原代淋巴细胞反应降低和肌肉提取物中C3水平降低有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号