• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Cholinergic and serotonergic activities are required in triggering conditioned NK cell response.
【24h】

Cholinergic and serotonergic activities are required in triggering conditioned NK cell response.

机译：触发条件性NK细胞反应需要胆碱能和血清素能活动。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of the study was to examine the importance of the cholinergic system in triggering the conditioned NK cell response. The fact that serotonergic system can modulate cholinergic functions suggested that it might be involved in conditioned NK cell response. To evaluate the potential pathways, cholinergic and serotonergic antagonists were applied centrally at either the conditioned association or recall stage, to interfere with the conditioned NK cell response. The results showed that both the cholinergic and serotonergic systems were necessary for eliciting the conditioned enhancement of NK cell activity. Involvements of the two systems were found to be critical for establishing the conditioned association and recall of the conditioned response. The blocks are believed to be receptor mediated. The receptors identified to be involved in the regulation of the conditioned NK cell response were: M(1), M(2) and M(3) muscarinic; nicotinic; 5 HT(1) and 5 HT(2) receptors.
机译：这项研究的目的是检查胆碱能系统在触发条件性NK细胞反应中的重要性。血清素能系统可调节胆碱能功能的事实表明，它可能参与条件性NK细胞反应。为了评估潜在的途径，在条件关联或回忆阶段集中应用胆碱能和血清素能拮抗剂，以干扰条件NK细胞反应。结果表明，胆碱能系统和血清素能系统均是引起条件性NK细胞活性增强所必需的。发现两个系统的参与对于建立条件关联和回忆条件响应至关重要。据信这些阻断是受体介导的。被确定参与条件性NK细胞反应调节的受体为：M（1），M（2）和M（3）毒蕈碱;烟; 5 HT（1）和5 HT（2）受体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号