• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor.
【24h】

Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor.

机译：白介素-1受体拮抗剂在海马中发挥激动剂活性，而与白介素-1 I型受体无关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Interleukin-1 receptor antagonist (IL-1ra) selectively and competitively inhibits the actions of IL-1 at its receptors and has not been reported to have agonist activity. This study demonstrates that stimulation of synaptosomes with IL-1ra in vitro, mimicked the effects of IL-1 beta by decreasing glutamate release and increasing JNK phosphorylation. These effects of IL-1ra, but not IL-1 beta, were maintained in IL-1 type I receptor (IL-1RI) defective mice. IL-1 beta blocked these IL-1ra-induced effects suggesting that it may also act independently of IL-1RI in some circumstances. Furthermore, IL-1ra mimicked the inhibitory effect of IL-1 beta on long-term potentiation (LTP) in the hippocampus. These data, taken together with our findings that IL-1ra binds to hippocampal synaptosomes in the absence of IL-1RI, provide evidence that IL-1ra exerts agonist activity in the hippocampus independent of IL-1RI.
机译：白介素-1受体拮抗剂（IL-1ra）选择性和竞争性地抑制IL-1对其受体的作用，尚未有激动剂的报道。这项研究表明，在体外用IL-1ra刺激突触体可通过减少谷氨酸盐释放和增加JNK磷酸化来模仿IL-1β的作用。 IL-1ra的这些效应在IL-1 I型受体（IL-1RI）缺陷小鼠中得以维持，但IL-1 beta却没有。 IL-1β阻断了这些IL-1ra诱导的作用，表明在某些情况下它也可能独立于IL-1RI发挥作用。此外，IL-1ra模仿了IL-1β对海马长时程增强（LTP）的抑制作用。这些数据与我们的发现（在没有IL-1RI的情况下，IL-1ra与海马突触体结合）一起提供了证据，证明IL-1ra在海马中发挥激动剂活性，独立于IL-1RI。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号