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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >GM1 antibodies in post-polio syndrome and previous paralytic polio.
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GM1 antibodies in post-polio syndrome and previous paralytic polio.

机译：脊髓灰质炎后综合征和先前的麻痹性脊髓灰质炎的GM1抗体。

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摘要

We studied the relationship between post-polio syndrome (PPS) and GM1 antibodies, since such antibodies have been associated with PPS and motor neuron disorders. Sera from 144 patients with previous poliomyelitis (105 paralytic, 22 nonparalytic and 17 PPS), 60 with previous Guillain-Barre syndrome, 44 with amyotrophic lateral sclerosis (ALS) and 22 healthy blood donors were analyzed with ELISA for GM1 IgM, IgG and IgA antibodies. GM1 antibodies were present in 14% of the PPS patients, but the prevalence did not differ significantly from that of the other groups. Our study does not support the hypothesis that GM1 antibodies are involved in the pathogenesis of PPS.
机译：我们研究了脊髓灰质炎后综合征（PPS）和GM1抗体之间的关系，因为此类抗体已与PPS和运动神经元疾病相关。使用ELISA分析了144例先前脊髓灰质炎患者（105例麻痹，22例非麻痹和17 PPS），60例先前格林巴利综合征，44例肌萎缩性侧索硬化症（ALS）和22名健康献血者的血清中GM1 IgM，IgG和IgA抗体。 GM1抗体存在于14％的PPS患者中，但其患病率与其他组没有显着差异。我们的研究不支持GM1抗体参与PPS发病机理的假说。

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