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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Dysregulation of the hypothalamic-pituitary-gonadal axis in experimental autoimmune encephalomyelitis and multiple sclerosis.
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Dysregulation of the hypothalamic-pituitary-gonadal axis in experimental autoimmune encephalomyelitis and multiple sclerosis.

机译：实验性自身免疫性脑脊髓炎和多发性硬化症的下丘脑-垂体-性腺轴失调。

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摘要

The ability of sex hormones to regulate cytokine production is well established, but the ability of cytokines to regulate sex hormone production has only begun to be investigated. We measured sex hormones in mice with passive experimental autoimmune encephalomyelitis (EAE) and in multiple sclerosis (MS) patients with sexual dysfunction. Abnormally low serum testosterone levels were found in male mice with EAE and in male MS patients, while serum estrogen levels in female mice with EAE were normal. An inverse relationship between cytokine and testosterone levels in male mice with EAE, coupled with an increase in serum luteinizing hormone (LH) levels, suggests that inflammatory cytokines suppress testosterone production by a direct effect on testicular Leydig cells. Gender differences in the sensitivity of the hypothalamic-pituitary-gonadal (HPG) axis to inflammation may be an important factor regulating the duration and severity of central nervous system (CNS) autoimmunity.
机译：性激素调节细胞因子产生的能力已经很成熟，但是细胞因子调节性激素产生的能力才刚刚被研究。我们在患有被动实验性自身免疫性脑脊髓炎（EAE）的小鼠和患有性功能障碍的多发性硬化症（MS）患者中测量了性激素。在患有EAE的雄性小鼠和雄性MS患者中，血清睾丸激素水平异常低，而患有EAE的雌性小鼠的血清雌激素水平正常。 EAE雄性小鼠的细胞因子与睾丸激素水平成反比，再加上血清黄体生成激素（LH）水平的升高，表明炎症细胞因子通过直接作用于睾丸Leydig细胞抑制睾丸激素的产生。下丘脑-垂体-性腺（HPG）轴对炎症敏感性的性别差异可能是调节中枢神经系统（CNS）自身免疫持续时间和严重程度的重要因素。

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