首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA.
【24h】

CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA.

机译:人脐带血中的CD34阳性细胞表达神经生长因子及其特异性受体TrkA。

获取原文
获取原文并翻译 | 示例
           

摘要

In this study, we investigated whether hematopoietic stem cells (HSC) and progenitors present in human cord blood can express nerve growth factor (NGF)-specific receptors, TrkA and p75. Our results showed a marked expression of TrkA and NGF in cord blood CD34(+) cells. A gradient of TrkA and NGF expression exists and is highest in cord blood CD34(+) cells, reduced in cord blood mononuclear cells (MNC) and minimal in mononuclear cells isolated from adult peripheral blood.Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity.
机译:在这项研究中,我们调查了人类脐带血中存在的造血干细胞(HSC)和祖细胞是否可以表达神经生长因子(NGF)特异性受体TrkA和p75。我们的结果显示脐血CD34(+)细胞中TrkA和NGF的明显表达。 TrkA和NGF表达存在梯度,在脐血CD34(+)细胞中最高,在脐血单核细胞(MNC)中降低,而在从成年外周血中分离的单核细胞中最低。造血祖细胞的分化,并表明免疫细胞对NGF的需求不同,这取决于它们的成熟状态。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号