The monocyte chemotactic protein-1 -2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid.

Letendre S; Marquie Beck J; Singh KK; de Almeida S; Zimmerman J; A Spector S; Grant I; Ellis R

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >The monocyte chemotactic protein-1 -2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid.

【24h】

The monocyte chemotactic protein-1 -2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid.

机译：单核细胞趋化蛋白-1 -2578G等位基因与脑脊液中MCP-1浓度升高有关。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Because monocyte chemotactic protein (MCP)-1 is an important cofactor in HIV neuropathogenesis, we investigated the relationship between MCP-1 genotype and expression in cerebrospinal fluid (CSF). We evaluated a genetic polymorphism in the MCP-1 promoter at position -2578 (alternatively designated -2518) in 98 HIV-infected subjects who had contemporaneously collected plasma and CSF. CSF MCP-1 levels were highest in the G/G genotype group, intermediate in the G/A group, and lowest in the A/A group. MCP-1 levels in plasma only differed by genotype after adjusting for HIV-related factors. Our findings suggest that this MCP-1 promoter polymorphism influences HIV neuropathogenesis by regulating MCP-1 protein expression in the central nervous system (CNS).

机译：由于单核细胞趋化蛋白（MCP）-1是HIV神经发病机制中的重要辅助因子，因此我们研究了MCP-1基因型与脑脊液（CSF）表达之间的关系。我们评估了98名同时感染血浆和脑脊液的HIV感染者中MCP-1启动子在-2578位（或-2518）的遗传多态性。 CSF MCP-1水平在G / G基因型组中最高，在G / A组中居中，在A / A组中最低。校正HIV相关因素后，血浆中MCP-1水平仅因基因型而异。我们的发现表明，该MCP-1启动子多态性通过调节中枢神经系统（CNS）中的MCP-1蛋白表达来影响HIV神经发病机制。

著录项

来源
《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2004年第2期|共4页
作者
Letendre S; Marquie Beck J; Singh KK; de Almeida S; Zimmerman J; A Spector S; Grant I; Ellis R;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Monocyte Chemoattractant Protein-1; Proteins; HIV; Monocytes; 单核细胞化学吸引蛋白质1; 蛋白质类; 单核细胞;

机译：Monocyte Chemoattractant Protein-1;Proteins;HIV;Monocytes;单核细胞化学吸引蛋白质1;蛋白质类;单核细胞;

相似文献

外文文献
中文文献
专利

1. The monocyte chemotactic protein-1 -2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid. [J] . Letendre S, Marquie Beck J, Singh KK, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2004,第1a2期

机译：单核细胞趋化蛋白-1 -2578G等位基因与脑脊液中MCP-1浓度升高有关。
2. Inhibitor of inflammation, peptide fragment (65-76) of monocyte chemotactic protein-1 (MCP-1), inhibits binding of MCP-1 to heparin [J] . Krasnikova T.L., Nikitin P.I., Ksenevich T.I., Biochemistry (Moscow). Supplement, Series A. Membrane and cell biology . 2011,第1期

机译：炎症抑制剂单核细胞趋化蛋白1（MCP-1）的肽片段（65-76）抑制MCP-1与肝素的结合
3. Synthetic peptide fragment (65–76) of monocyte chemotactic protein-1 (MCP-1) inhibits MCP-1 binding to heparin and possesses anti-inflammatory activity in stable angina patients after coronary stenting [J] . T. I. Arefieva, T. L. Krasnikova, A. V. Potekhina, Inflammation Research . 2011,第10期

机译：单核细胞趋化蛋白-1（MCP-1）的合成肽片段（65-76）抑制MCP-1与肝素的结合，并在稳定的心绞痛患者冠状动脉支架置入后具有抗炎活性
4. INCREASED MONOCYTE CHEMOTACTIC PROTEIN-1 CONCENTRATIONS ARE ASSOCIATED WITH DECREASED DISEASE-FREE INTERVAL AND SURVIVAL TIME IN DOGS WITH LYMPHOMA [C] . James Perry, Joe Sottnik, Dahlia Rice, Annual Conference of the Veterinary Cancer Society . 2009

机译：增加单核细胞趋化蛋白-1浓度与淋巴瘤的狗的无病间间隔和生存时间有关
5. Marker-assisted selection for elevated concentrations of the alpha' subunit of beta-conglycinin, evaluation of its influence on agronomic and seed traits, and mapping of the mutant fap4(A24) allele for elevated palmitate concentration in soybean. [D] . Oltmans-Deardorff, Sheilah Emilie. 2012

机译：β-伴大豆球蛋白α'亚基浓度升高的标记辅助选择，评估其对农艺和种子性状的影响，并绘制突变的fap4（A24）等位基因作图，以测定大豆中棕榈酸酯浓度的升高。
6. Augmented production of chemokines (monocyte chemotactic protein-1 (MCP-1) macrophage inflammatory protein-1α (MIP-1α) and MIP-1β) in patients with systemic sclerosis: MCP-1 and MIP-1α may be involved in the development of pulmonary fibrosis [O] . M HASEGAWA, S SATO, K TAKEHARA 1999

机译：系统性硬化患者趋化因子（单核细胞趋化蛋白-1（MCP-1）巨噬细胞炎性蛋白-1α（MIP-1α）和MIP-1β）的产生增加：MCP-1和MIP-1α可能参与了该过程肺纤维化
7. Augmented production of chemokines (monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α) and MIP-1β) in patients with systemic sclerosis: MCP-1 and MIP-1α may be involved in the development of pulmonary fibrosis [O] . HASEGAWA, M, SATO, S, TAKEHARA, K 1999

机译：系统性硬化患者趋化因子（单核细胞趋化蛋白-1（MCP-1），巨噬细胞炎性蛋白-1α（MIP-1α）和MIP-1β）的产生增加：MCP-1和MIP-1α可能参与了该过程肺纤维化

The monocyte chemotactic protein-1 -2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid.

摘要

著录项

相似文献

相关主题

期刊订阅