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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Phenotypes indicating cytolytic properties of Borrelia-specific interferon-gamma secreting cells in chronic Lyme neuroborreliosis.
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Phenotypes indicating cytolytic properties of Borrelia-specific interferon-gamma secreting cells in chronic Lyme neuroborreliosis.

机译：表型表明在慢性莱姆神经疏螺旋体中疏螺旋体特异性干扰素-γ分泌细胞的溶细胞特性。

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摘要

The immuno-pathogenetic mechanisms underlying chronic Lyme neuroborreliosis are mainly unknown. Human Borrelia burgdorferi (Bb) infection is associated with Bb-specific secretion of interferon-gamma (IFN-gamma), which may be important for the elimination of Bb, but this may also cause tissue injury. In order to increase the understanding of the pathogenic mechanisms in chronic neuroborreliosis, we investigated which cell types that secrete IFN-gamma. Blood mononuclear cells from 13 patients with neuroborreliosis and/or acrodermatitis chronicum atrophicans were stimulated with Bb antigen and the phenotypes of the induced IFN-gamma-secreting cells were analyzed with three different approaches. Cells expressing CD8 or TCRgammadelta, which both have cytolytic properties, were the main phenotypes of IFN-gamma-secreting cells, indicating that tissue injury in chronic neuroborreliosis may be mediated by cytotoxic cells.
机译：慢性莱姆病神经硼蛋白沉着症的免疫病理机制主要未知。人伯氏疏螺旋体（Bb）感染与Bb特异性干扰素-γ（IFN-γ）分泌有关，这对消除Bb可能很重要，但这也可能导致组织损伤。为了加深对慢性神经硼化病的致病机制的了解，我们研究了分泌IFN-γ的细胞类型。用Bb抗原刺激13例神经衰弱和/或慢性萎缩性acrophititis萎缩患者的血液单核细胞，并用三种不同方法分析诱导的IFN-γ分泌细胞的表型。表达CD8或TCRgammadelta的细胞均具有溶细胞特性，是IFN-γ分泌细胞的主要表型，表明慢性神经性贝氏体病的组织损伤可能是由细胞毒性细胞介导的。

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