• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Myocardial ischemia alters immunoregulatory cell traffic and function in the rat independent of exogenous catecholamine administration.
【24h】

Myocardial ischemia alters immunoregulatory cell traffic and function in the rat independent of exogenous catecholamine administration.

机译：独立于外源儿茶酚胺的给药，心肌缺血可改变大鼠的免疫调节细胞流量和功能。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent investigation has suggested there is an adrenergically-driven efflux of beta 2-receptor rich lymphocyte subsets into the circulation with altered function following either exercise or infusion of exogenous catecholamines. Myocardial ischemia, like exercise, is associated with generalized sympathoadrenal activation. To determine whether ischemia influences immunoregulatory cell traffic and function in a manner comparable to beta 2-adrenergic stimulation via isoproterenol, rats underwent thoracotomy with or without coronary ligation. Another group of rats received either isoproterenol (1 mg/kg) or vehicle (10 mM HCl) intraperitoneally. Thoracotomy, regardless of whether or not myocardial ischemia was induced, led to lymphocytosis, reflected primarily by an increase in Thelper (Th) cells and, to a lesser degree, in Tsuppressor/cytotoxic (Ts/c) and natural killer (NK) cells, with a tendency toward an increased Th/Ts/c ratio. To the contrary, isoproterenol injection resulted in a relative lymphopeniacharacterized by diminished B and Th cell numbers, preserved Ts/c and increased NK cell numbers leading to a significant decrease in the Th/Ts/c ratio. With respect to splenic composition, 60 but not 15 min of myocardial ischemia led to diminished Th and B cell numbers compared to sham operated controls, whereas isoproterenol appeared to stimulate an efflux of only NK cells. Both ischemia and isoproterenol enhanced basal splenocyte function; however, only ischemia significantly boosted splenocyte responsiveness to the mitogen Concanavalin A. Surgically induced myocardial ischemia leads to alterations in immunoregulatory cell migration and function which are distinct from those found with beta 2-adrenergic stimulation via isoproterenol.
机译：最近的研究表明，在运动或输注外源儿茶酚胺后，肾上腺素驱动的富含β2受体的淋巴细胞亚群进入循环功能改变的循环。像运动一样，心肌缺血与广泛性交感肾上腺激活有关。为了确定缺血是否以与异丙肾上腺素β2-肾上腺素刺激相当的方式影响免疫调节细胞的运输和功能，对大鼠进行了有或没有冠状动脉结扎术的开胸手术。另一组大鼠腹膜内接受异丙肾上腺素（1 mg / kg）或赋形剂（10 mM HCl）。不论是否诱发心肌缺血，开胸手术都会导致淋巴细胞增多，主要表现为Thelper（Th）细胞的增加，而Tsubpressor /细胞毒性（Ts / c）和自然杀伤（NK）细胞的增加较少，有增加Th / Ts / c比的趋势。相反，异丙肾上腺素注射导致相对的淋巴细胞减少，其特征在于B和Th细胞数目减少，Ts / c保留和NK细胞数目增加，导致Th / Ts / c比率显着降低。关于脾脏组成，与假手术对照组相比，心肌缺血60分钟（而不是15分钟）导致Th和B细胞数量减少，而异丙肾上腺素似乎仅刺激NK细胞外排。缺血和异丙肾上腺素均可增强基础脾细胞功能;但是，只有缺血才能显着增强脾细胞对促细胞分裂素伴刀豆球蛋白A的反应性。外科手术诱发的心肌缺血会导致免疫调节细胞迁移和功能发生改变，这与通过异丙肾上腺素β2肾上腺素刺激发现的改变不同。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号