首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Intravenous catecholamine administration affects mouse intestinal lymphocyte number and apoptosis.
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Intravenous catecholamine administration affects mouse intestinal lymphocyte number and apoptosis.

机译:静脉给予儿茶酚胺会影响小鼠肠道淋巴细胞数量和凋亡。

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摘要

The purposes of this study were to determine plasma and intestinal epinephrine (E) and norepinephrine (NE) concentrations in mice after exercise stress and, the effect of intravenous injection of E and NE (at concentrations during exercise) on viability of intestinal lymphocytes (IL). Exhaustive exercise significantly elevated plasma E and NE, and intestinal E, compared with sedentary animals. Twenty-four hours after intravenous NE administration, IL counts were higher (p<0.001) and % apoptotic IL were lower (p<0.001) than saline conditions. E resulted in fewer apoptotic IL at 24 h compared to saline controls. E and NE differentially influence IL numbers at 24 h after injection although both result in fewer % apoptotic IL relative to mice given saline only.
机译:这项研究的目的是确定运动应激后小鼠血浆和肠道肾上腺素(E)和去甲肾上腺素(NE)的浓度,以及静脉注射E和NE(在运动期间的浓度)对肠道淋巴细胞(IL)活力的影响)。与久坐的动物相比,力竭运动显着提高血浆E和NE以及肠道E。静脉内NE给药后二十四小时,与生理盐水相比,IL计数更高(p <0.001),而凋亡IL%更低(p <0.001)。与盐水对照相比,E在24 h导致更少的凋亡IL。 E和NE差异影响注射后24小时的IL值,尽管相对于仅给予生理盐水的小鼠,它们均导致更少的凋亡IL%。

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