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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Proteomic fingerprinting of HIV-1-infected human monocyte-derived macrophages: a preliminary report.
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Proteomic fingerprinting of HIV-1-infected human monocyte-derived macrophages: a preliminary report.

机译：HIV-1感染的人类单核细胞衍生的巨噬细胞的蛋白质组指纹图谱：初步报告。

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摘要

Mononuclear phagocytes (MP; blood monocytes, alveolar, lymph node, and brain macrophages and microglia) are vehicles for dissemination and principle target cells for human immunodeficiency virus type 1 (HIV-1) infection. Notably, viral persistence in macrophages occurs despite ongoing phagocytic, intracellular killing, innate and adaptive immune responses. To assess potential pathways for how HIV-1 may bypass antiviral MP responses, we used proteomic tests to evaluate protein fingerprints of HIV-1-infected human monocyte-derived macrophages 7 days after viral infection. By using weak cation exchange chips, 58 proteins were found up- or down-regulated after HIV-1(ADA) infection. Several of these proteins were identified by microsequencing. It is probable that cellular proteins identified by proteomic fingerprinting could assist in unraveling how persistent viral infection occurs in MP lineage cells. Moreover, this evolving technology can be utilized to unravel changes in immune activities initiated by interactions between virus, environmental cues and drugs of abuse.
机译：单核吞噬细胞（MP;血液单核细胞，肺泡，淋巴结以及脑巨噬细胞和小胶质细胞）是传播工具，是人类1型免疫缺陷病毒（HIV-1）感染的主要靶细胞。值得注意的是，尽管吞噬，细胞内杀伤，先天性和适应性免疫反应持续存在，但巨噬细胞仍存在病毒残留。为了评估HIV-1如何绕过抗病毒MP反应的潜在途径，我们使用蛋白质组学测试来评估病毒感染7天后被HIV-1感染的人单核细胞衍生的巨噬细胞的蛋白质指纹。通过使用弱阳离子交换芯片，发现HIV-1（ADA）感染后58种蛋白质被上调或下调。通过微测序鉴定了这些蛋白质中的几种。通过蛋白质组指纹图谱鉴定的细胞蛋白很可能有助于阐明MP谱系细胞中持续性病毒感染的发生方式。而且，这种不断发展的技术可以用来揭示由病毒，环境线索和滥用药物之间的相互作用引发的免疫活动的变化。

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