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The mast cells of the multiple sclerosis brain.

机译:多发性硬化脑的肥大细胞。

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摘要

Traditional staining methods, plus indirect immunoperoxidase techniques for IgE and mast cell tryptase (MCTr) were used to study the mast cells (MCs) of multiple sclerosis (MS) and normal brains. The MCs varied in number in MS amongst perivascular inflammatory cells as well as free in the parenchyma, especially inside and around "chronic active' plaques. Since MCs do not migrate, and rarely divide in maturity, they must have developed locally. Staining for IgE was moderately strong on and within MCs, and weak within some plasma cells. MCTr reacted strongly both within CNS and outside it. Being a strong neutral proteinase. MCTr, plus IgE, could conceivably have played some role in the pathogenesis of the MS plaques.
机译:传统的染色方法,加上间接免疫过氧化物酶技术用于IgE和肥大细胞类胰蛋白酶(MCTr),用于研究多发性硬化症(MS)和正常大脑的肥大细胞(MCs)。 MCs在血管周围炎性细胞之间以及在实质组织中的游离中,在MC中的数目各不相同,特别是在“慢性活性”斑块内部和周围。由于MCs不迁移并且很少成熟,因此它们一定是局部发育的。在MCS上和MCS内中等强度,在某些浆细胞内弱,MCTr在CNS内外均强烈反应,是强中性蛋白酶,MCTr加上IgE可能在MS斑块的发病中起一定作用。

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