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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Sex differences in susceptibility to viral infection of the central nervous system.
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Sex differences in susceptibility to viral infection of the central nervous system.

机译：中枢神经系统病毒感染易感性的性别差异。

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摘要

We have characterized striking differences in recovery of male and female BALB/c and BALB/c-H-2dm2 (dm2) mice from an experimental neurotropic viral infection of the central nervous system (CNS). Following intranasal inoculation of vesicular stomatitis virus (VSV), assays of tissue homogenates from female mice produced lower viral titers. There was also a significant reduction in the spread of virus from the rostral to caudal end of the brain in female mice. Enhanced recovery by female mice of both strains in response to this viral insult correlates with increased levels of Nitric Oxide Synthase (NOS) types I, II, and III expression, an increased prevalence of reactive astrocytes, earlier and enhanced levels of expression of Major Histocompatibility Complex (MHC) class II molecules on astrocytes, endothelial and microglial cells, and increased T cell infiltration in the female BALB/c mouse. Taken together, these findings document sexual dimorphism in CNS immunity, and may provide an understanding of some of the mechanisms underlying many sex-biased diseases.
机译：我们已经从中枢神经系统（CNS）的实验性嗜神经性病毒感染中恢复了雄性和雌性BALB / c和BALB / c-H-2dm2（dm2）小鼠的显着差异。鼻内接种水疱性口炎病毒（VSV）后，对雌性小鼠组织匀浆的测定产生了较低的病毒滴度。在雌性小鼠中，病毒从脑的尾端到尾端的传播也明显减少。雌性小鼠响应此病毒侵害而恢复的增强与I，II和III型一氧化氮合酶（NOS）表达水平升高，反应性星形胶质细胞患病率增加，主要组织相容性表达较早和表达水平升高有关雌性BALB / c小鼠中星形胶质细胞，内皮细胞和小胶质细胞上的复合物（MHC）II类分子，并增加了T细胞浸润。综上所述，这些发现证明了CNS免疫中的性二态性，并可能提供了对许多性别歧视性疾病的潜在机制的理解。

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