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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Vaccination with peptides from MHC class II beta chain hypervariable region causes allele-specific suppression of EAE.
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Vaccination with peptides from MHC class II beta chain hypervariable region causes allele-specific suppression of EAE.

机译：用来自MHC II类β链高变区的肽进行疫苗接种会导致EAE的等位基因特异性抑制。

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摘要

In our earlier studies we showed that successful immunotherapy of EAE in SJL/J mice can be achieved either by the use of antibodies to MHC class II antigens or by vaccination with synthetic peptide analogs of the beta chain of MHC class II molecules. We proposed that inhibition of EAE following vaccination with synthetic peptides derived from the beta chain of mouse I-A, was in part due to the generation of auto-anti-MHC class II antibodies that interfered with T cell sensitization. In our present study we show that suppression of EAE following vaccination results in poor sensitization of MBP reactive T cells, and that the lack of immune response is allele-specific. In F1(SJL(I-AS) x Balb/cI-Ad) mice, in which susceptibility to EAE is linked closely to the I-AS allele, vaccination with peptides from beta chain of I-AS results in inhibition of proliferative response to MBP and prevents the development of EAE. Vaccination with peptide from the beta chain of I-Ad did not affect either the development of immune response to MBP or the induction of EAE, indicating allele-specific suppression. Since global immunosuppression is not induced by vaccination with I-A peptides, we propose that this strategy can be extended to human autoimmune diseases wherein a clear association between certain MHC class II alleles and autoimmune disease is evident.
机译：在我们较早的研究中，我们表明，通过使用针对MHC II类抗原的抗体或通过接种MHC II类分子的β链的合成肽类似物，可以实现SJL / J小鼠中EAE的成功免疫治疗。我们提出，接种源自小鼠I-Aβ链的合成肽后，对EAE的抑制作用部分是由于干扰T细胞致敏作用的自身抗MHC II类抗体的产生。在我们目前的研究中，我们显示出接种疫苗后抑制EAE会导致MBP反应性T细胞的敏感性降低，并且缺乏免疫应答是等位基因特异性的。在F1（SJL（I-AS）x Balb / cI-Ad）小鼠中，对EAE的易感性与I-AS等位基因紧密相关，接种I-ASβ链肽段可抑制对EAE的增殖反应MBP并阻止了EAE的发展。用来自I-Adβ链的肽进行疫苗接种不会影响对MBP的免疫反应的发展或对EAE的诱导，这表明等位基因特异性抑制。由于用I-A肽疫苗接种不会诱导整体免疫抑制，因此我们建议将这种策略扩展到人类自身免疫性疾病，其中某些MHC II类等位基因与自身免疫性疾病之间有明显的联系。

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