Antibodies against fetal brain in sera of mothers with autistic children.

Singer HS; Morris CM; Gause CD; Gillin PK; Crawford S; Zimmerman AW

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Antibodies against fetal brain in sera of mothers with autistic children.

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Antibodies against fetal brain in sera of mothers with autistic children.

机译：患有自闭症儿童的母亲血清中针对胎儿脑的抗体。

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Serum antibodies in 100 mothers of children with autistic disorder (MCAD) were compared to 100 age-matched mothers with unaffected children (MUC) using as antigenic substrates human and rodent fetal and adult brain tissues, GFAP, and MBP. MCAD had significantly more individuals with Western immunoblot bands at 36 kDa in human fetal and rodent embryonic brain tissue. The density of bands was greater in fetal brain at 61 kDa. MCAD plus developmental regression had greater reactivity against human fetal brain at 36 and 39 kDa. Data support a possible complex association between genetic/metabolic/environmental factors and the placental transfer of maternal antibodies in autism.

机译：使用人类和啮齿动物的胎儿和成年脑组织，GFAP和MBP作为抗原底物，将100名自闭症儿童（MCAD）母亲的血清抗体与100名年龄匹配的未患病儿童（MUC）的母亲进行了比较。 MCAD在人类胎儿和啮齿动物的胚胎脑组织中有36 kDa具有Western免疫印迹带的个体明显更多。在61 kDa的胎脑中，条带的密度更大。 MCAD和发育消退在36和39 kDa时对人胎脑的反应性更高。数据支持遗传/代谢/环境因素与自闭症中母体抗体的胎盘转移之间可能的复杂关联。

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来源
《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2008年第2期|共8页
作者
Singer HS; Morris CM; Gause CD; Gillin PK; Crawford S; Zimmerman AW;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
关键词
Foetal; Brain; Child; Human; Antibodies; in vitro diagnostic; 脑; 儿童;

机译：Foetal;Brain;Child;Human;Antibodies;in vitro diagnostic;脑;儿童;

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专利

1. Antibodies against fetal brain in sera of mothers with autistic children. [J] . Singer HS, Morris CM, Gause CD, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2008,第1a2期

机译：患有自闭症儿童的母亲血清中针对胎儿脑的抗体。
2. Radioimmunologic Measurements of Naturally Occurring Antibodies. III. Antibodies Reactive with Escherichia coli or Bacteroides fragilis in Breast Fluids and Sera of Mothers and Newborn Infants [J] . Micheline T Ste-Marie, Evelyn M Lee, William R Brown Pediatric Research . 1974,第9期

机译：天然存在抗体的放射免疫学测量。三，与母体和新生儿的母乳和血清中的大肠杆菌或脆弱拟杆菌（Bacteroides fragilis）具有反应性的抗体
3. Serum anti-nuclear antibodies as a marker of autoimmunity in Egyptian autistic children. [J] . Mostafa GA, Kitchener N Pediatric neurology . 2009,第2期

机译：血清抗核抗体可作为埃及自闭症儿童自身免疫的标志物。
4. The application of digital image analysis for blood typing - the comparison of anti-A and anti-B monoclonal antibodies activity with standard hemagglutinating sera [C] . Maria F. Medvedeva, Valery A. Doubrovski Optical Technologies in Biophysics Medicine . 2017

机译：数字图像分析对血液键入的应用 - 抗A和抗B单克隆抗体活性与标准血凝血清的比较
5. The Development of an ELISA for the Quantification of Antibodies Against CD52g, a Sperm Coating Glycoprotein, in the Sera of Patients with Infertility [D] . Marcus , Claire E. 2020

机译：用于在患有不孕症患者的血清中对CD52G进行抗体的抗体进行抗体的ELISA的开发
6. Antibody-dependent cellular cytotoxicity and neutralizing activity in sera of HIV-1-infected mothers and their children. [O] . K Broliden, E Sievers, P A Tovo, 1993

机译：HIV-1感染的母亲及其子女血清中的抗体依赖性细胞毒性和中和活性。
7. Antibody-dependent cellular cytotoxicity and neutralizing activity in sera of HIV-1-infected mothers and their children. [O] . Broliden, K, Sievers, E, Tovo, P A, 2008

机译：HIV-1感染的母亲及其子女血清中的抗体依赖性细胞毒性和中和活性。
8. Rickettsia tsutsugamushi Antibody in Mother/Cord Pairs of Sera [R] . Shirai, A., Brown, G. W., Gan, E., 1980

机译：Rickettsia tsutsugamushi抗体在母亲/ Cord对血清

Antibodies against fetal brain in sera of mothers with autistic children.

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