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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >The astrocytic response in early experimental autoimmune encephalomyelitis occurs across both the grey and white matter compartments.
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The astrocytic response in early experimental autoimmune encephalomyelitis occurs across both the grey and white matter compartments.

机译：早期实验性自身免疫性脑脊髓炎的星形胶质细胞反应横跨灰质和白质区室。

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摘要

An unexpectedly prominent aspect of murine experimental autoimmune encephalomyelitis is pre-onset astrocyte reactivity. Further examination of this phenomenon in the spinal cord demonstrates that grey matter, as well as white matter astrocytes, change their morphology and cell density from the earliest disease manifestation. Comparison of the two compartments reveals that, whereas white matter changes are rostro-caudally consistent, grey matter reactivity is spatially restricted and of varying amplitude between spinal cord levels. These data strongly suggest that in neuroinflammation early, cross-compartmental recruitment of astrocytes occurs, but with different expression patterns.
机译：鼠类实验性自身免疫性脑脊髓炎一个出乎意料的突出方面是发病前的星形胶质细胞反应性。对脊髓中这种现象的进一步检查表明，灰质以及白质星形胶质细胞从最早的疾病表现开始就改变了它们的形态和细胞密度。对这两个部分的比较显示，尽管白质的变化在头尾尾一致，但灰质的反应性在空间上受到限制，并且在脊髓水平之间具有变化的幅度。这些数据强烈表明，在神经炎症早期，星形胶质细胞发生跨室募集，但是具有不同的表达方式。

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