Imatinib mesylate ameliorates the dystrophic phenotype in exercised mdx mice.

Bizario JC; Cerri DG; Rodrigues LC

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Imatinib mesylate ameliorates the dystrophic phenotype in exercised mdx mice.

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Imatinib mesylate ameliorates the dystrophic phenotype in exercised mdx mice.

机译：甲磺酸伊马替尼改善了运动的mdx小鼠的营养不良表型。

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Myofiber degeneration, inflammation, and fibrosis are remarkable features of Duchenne muscular dystrophy. We hypothesized that the administration of imatinib mesylate, an inhibitor of tyrosine kinase and TGF-beta pro-fibrogenic activity, could improve the muscular conditions in mdx mice. Four-week old mdx mice were treated and exercised for 6 weeks. Gastrocnemius and diaphragm histopathology, strength, creatine kinase, and cytokine levels were evaluated. The treated group presented increased muscular strength and decreased CK levels, injured myofibers, and inflammatory infiltrates. Pro-inflammatory cytokines and TGF-beta were also reduced, while IL-10 was increased, suggesting an immunomodulatory effect of imatinib, which can ameliorate the dystrophic phenotype in mdx mice.

机译：肌纤维变性，炎症和纤维化是杜氏肌营养不良症的显着特征。我们假设甲磺酸伊马替尼（一种酪氨酸激酶和TGF-β促纤维化活性的抑制剂）的给药可以改善mdx小鼠的肌肉状况。治疗四周大的mdx小鼠，并锻炼6周。评估了腓肠肌和diaphragm肌的组织病理学，强度，肌酸激酶和细胞因子水平。治疗组表现出增加的肌肉力量和降低的CK水平，受伤的肌纤维和炎性浸润。促炎性细胞因子和TGF-β也降低，而IL-10升高，提示伊马替尼具有免疫调节作用，可改善mdx小鼠的营养不良表型。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2009年第2期|共9页
作者
Bizario JC; Cerri DG; Rodrigues LC;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
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1. Imatinib mesylate ameliorates the dystrophic phenotype in exercised mdx mice. [J] . Bizario JC, Cerri DG, Rodrigues LC Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2009,第1a2期

机译：甲磺酸伊马替尼改善了运动的mdx小鼠的营养不良表型。
2. Octa-guanidine morpholino restores dystrophin expression in cardiac and skeletal muscles and ameliorates pathology in dystrophic mdx mice. [J] . Wu B, Li Y, Morcos PA, Molecular therapy: the journal of the American Society of Gene Therapy . 2009,第5期

机译：八胍胍吗啉代可恢复肌营养不良蛋白在心肌和骨骼肌中的表达，并改善营养不良的mdx小鼠的病理。
3. Modulation of insulin-like growth factor (IGF)-I and IGF-binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice. [J] . Schertzer JD, Gehrig SM, Ryall JG, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2007,第4期

机译：胰岛素样生长因子（IGF）-I和IGF结合蛋白相互作用的调节增强了mdx小鼠的骨骼肌再生并改善了营养不良的病理学。
4. Combination Effects of Gambogic Acid on Imatinib Mesylate Cytotoxicity in Colon Cancer Cells [C] . El Mon Khaing, THANIKA Saenpunya, PITTAWAS Kerdklai International conference and exhibition on Pharmaceutical Sciences and Technology . 2020

机译：甘伐酸对伊马替尼甲磺酸盐细胞毒性在结肠癌细胞中的组合作用
5. Control of imatinib mesylate drug resistance in BCR-ABL+ leukemia. [D] . Bui, Melanie Rae. 2010

机译：控制BCR-ABL +白血病中甲磺酸伊马替尼的耐药性。
6. A Five-Repeat Micro-Dystrophin Gene Ameliorated Dystrophic Phenotype in the Severe DBA/2J-mdx Model of Duchenne Muscular Dystrophy [O] . Chady H. Hakim, Nalinda B. Wasala, Xiufang Pan, 2017

机译：严重的DBA / 2J-mdx模型在杜兴肌营养不良的严重的五重复微Dystrophin基因改善营养不良表型。
7. Heregulin ameliorates the dystrophic phenotype in mdx mice. [O] . Krag, TO, Bogdanovich, S, Jensen, CJ, 2004

机译：调蛋白改善了mdx小鼠的营养不良表型。
8. LAM Pilot Study with Imatinib Mesylate (LAMP 1). [R] . Strange, C. 2017

机译：用甲磺酸伊马替尼（Lamp 1）进行Lam试验研究。

Imatinib mesylate ameliorates the dystrophic phenotype in exercised mdx mice.

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