LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation.

Kubo M; Kamiya Y; Nagashima R; Maekawa T; Eshima K; Azuma S; Ohta E; Obata F

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation.

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LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation.

机译：LRRK2在B-2中表达，但在B-1 B细胞中不表达，并通过细胞激活而下调。

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LRRK2, the causal molecule of familial Parkinson's disease, is expressed strongly by one of the B cell subsets, B-2 cells, but not by the other subset, B-1 cells, in the mouse peritoneal cavity, spleen, and peripheral blood. Bone marrow pre-B cells or T cells exhibited little LRRK2 expression. LRRK2 expression was dramatically downregulated upon activation of B-2 cells with various types of stimulation. These results suggest that LRRK2, whose true function has not yet been clarified, may play some important role(s) in the development and function of B cells, particularly the maintenance of B-2 cells in a resting status.

机译：家族性帕金森氏病的病因分子LRRK2在小鼠腹膜腔，脾脏和外周血中由一种B细胞亚群B-2细胞强烈表达，而另一种B-1细胞亚种则没有表达。骨髓前B细胞或T细胞几乎没有LRRK2表达。各种类型的刺激激活B-2细胞后，LRRK2表达急剧下调。这些结果表明，其真正功能尚未阐明的LRRK2，可能在B细胞的发育和功能，尤其是B-2细胞在静止状态的维持中起重要作用。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2010年第2期|共6页
作者
Kubo M; Kamiya Y; Nagashima R; Maekawa T; Eshima K; Azuma S; Ohta E; Obata F;
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中图分类神经病学;
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1. LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation. [J] . Kubo M, Kamiya Y, Nagashima R, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2010,第1a2期

机译：LRRK2在B-2中表达，但在B-1 B细胞中不表达，并通过细胞激活而下调。
2. TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation. [J] . Vire B, David A, Wiestner A The Journal of Immunology: Official Journal of the American Association of Immunologists . 2011,第8期

机译：Fcmicro受体TOSO在慢性淋巴细胞性白血病B细胞上高度表达，在IgM结合后内在化，穿梭至溶酶体，并响应TLR激活而下调。
3. Downregulated LRRK2 gene expression inhibits proliferation and migration while promoting the apoptosis of thyroid cancer cells by inhibiting activation of the JNK signaling pathway [J] . Zheng-Cai Jiang, Xiao-Jun Chen, Qi Zhou, International journal of oncology . 2019,第1期

机译：下调的LRRK2基因表达通过抑制JNK信号通路的激活，抑制增殖和迁移，同时促进甲状腺癌细胞的凋亡
4. Thymosin β_4 Upregulates the Expression of Hepatocyte Growth Factor and Downregulates the Expression of PDGF-β Receptor in Human Hepatic Stellate Cells [C] . ELENA BARNAEVA, AGLADZE NADEZHDA, EWALD HANNAPPEL, . 2007

机译：胸腺素β_4上调人肝星状细胞中肝细胞生长因子的表达并下调PDGF-β受体的表达
5. Programming cellular gene expression by IKK mediated NF-kappaB activation. [D] . Massa, Paul Edward. 2004

机译：通过IKK介导的NF-κB激活来编程细胞基因表达。
6. Downregulated LRRK2 gene expression inhibits proliferation and migration while promoting the apoptosis of thyroid cancer cells by inhibiting activation of the JNK signaling pathway [O] . Zheng-Cai Jiang, Xiao-Jun Chen, Qi Zhou, -1

机译：下调的LRRK2基因表达通过抑制JNK信号通路的激活抑制增殖和迁移同时促进甲状腺癌细胞的凋亡
7. MicroRNA-30c-2* Expressed in Ovarian Cancer Cells Suppresses Growth Factor–Induced Cellular Proliferation and Downregulates the Oncogene BCL9 [O] . Wei Jia, Juliet O. Eneh, Supriya Ratnaparkhe, 2011

机译：MicroRNA-30C-2 *在卵巢癌细胞中表达抑制生长因子诱导的细胞增殖，下调癌基因BCL9
8. Role of Accessory Cells in B Cell Activation. III. Cellular Analysis of Primary Immune Response Deficits in CBA/N Mice: Presence of an Accessory Cell-B Cell Interaction Defect [R] . Boswell, S. H., Nerenberg, M. I., Scher, I., 1980

机译：辅助细胞在B细胞活化中的作用。 III。 CBa / N小鼠原发性免疫应答缺陷的细胞分析：附着细胞-B细胞相互作用缺陷的存在

LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation.

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