HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes.

de Graaf MT; de Beukelaar JW; Haasnoot GW; Levering WH; Rogemond V; Didelot A; Honnorat J; Gratama JW; Smitt PA

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes.

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HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes.

机译：HLA-DQ2 +个体易患Hu-Ab相关的副肿瘤神经综合症。

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BACKGROUND: Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS). OBJECTIVE: To identify genetic risk factors for Hu-PNS and investigate the role of T cells. METHODS: HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC). RESULTS: The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in HC. CONCLUSIONS: This study indicates an association between Hu-PNS and presence of HLA-DQ2 and HLA-DR3, which supports a role for CD4(+) T cells in the pathogenesis of Hu-PNS.

机译：背景：假设，T细胞参与与Hu抗体（Hu-PNS）相关的副肿瘤性神经系统综合征的发病机理。目的：确定Hu-PNS的遗传危险因素，并研究T细胞的作用。方法：比较53例Hu-PNS患者，24例小细胞肺癌（SCLC）患者和2440例健康对照者（HC）的HLA-A，B，DRB1和DQB1等位基因。结果：Hu-PNS患者的HLA-DQ2和HLA-DR3的频率均显着高于HC。结论：这项研究表明Hu-PNS与HLA-DQ2和HLA-DR3的存在之间的关联，这支持了CD4（+）T细胞在Hu-PNS发病机理中的作用。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2010年第2期|共3页
作者
de Graaf MT; de Beukelaar JW; Haasnoot GW; Levering WH; Rogemond V; Didelot A; Honnorat J; Gratama JW; Smitt PA;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
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1. HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes. [J] . de Graaf MT, de Beukelaar JW, Haasnoot GW, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2010,第1a2期

机译：HLA-DQ2 +个体易患Hu-Ab相关的副肿瘤神经综合症。
2. Lung cancer and paraneoplastic neurologic syndromes. Case report and review of the literature. [J] . Marco Rossato, Eva Zabeo, Marta Burei, Clinical lung cancer . 2013,第3期

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3. Utility of F-18 FDG PET/CT in screening for paraneoplastic neurological syndromes. [J] . Matsuhisa A, Toriihara A, Kubota K, Clinical nuclear medicine . 2012,第1期

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5. Neural mechanisms for bilateral force asymmetry during supine lower limb extensions in neurologically intact individuals and individuals with post -stroke hemiparesis. [D] . Simon, Ann Marie. 2008

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6. Neurological paraneoplastic syndromes. [O] . U Nath, R Grant 1997

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7. Anti-glial nuclear antibody: marker of lung cancer-related paraneoplastic neurological syndromes. [O] . Graus, F, Vincent, A, Pozo-Rosich, P, 2005

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8. Breast Tumor Immunity in the Paraneoplastic Neurologic Disorders [R] . Darnell, R. B. 1998

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HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes.

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