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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Frequent abnormalities of the immune system in gliomas and correlation with the WHO grading system of malignancy.
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Frequent abnormalities of the immune system in gliomas and correlation with the WHO grading system of malignancy.

机译：神经胶质瘤中免疫系统的频繁异常及其与WHO恶性肿瘤分级系统的关系。

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AIM: To investigate the cellular and humoral immunity status of gliomas, and their association with the WHO grading system. MATERIAL AND METHODS: We have conducted a case-control study of 49 patients with gliomas and 30 healthy controls. We used ELISA assays, radial immunodiffusion, indirect immunofluorescence, latex test and flow cytometry assays to estimate preoperative in serum the immunological profile. RESULTS: Patients with glioma had significantly reduced amounts of IL2 (p=0.000), TNF-a (p=0.033), IgG (p=0.011), IgA (p=0.027),C4 (p=0.026) ,CD3+ (p=0.001), CD4+ (p=0.000), CD8+ (p=0.002), ratio CD4/CD8 (p=0.000), CD19+ (p=0.04) and elevated IL10 (p=0.05) compared with healthy controls. No statistically significant differences were observed concerning viral agents, total NK cells, IgM, IgE, IL16, granzyme-b, RF, ANA, ENA, anti-dsDNA and anti-cardiolipin antibodies. A higher WHO grade, after controlling for age and gender, was associated with decreased number of CD3+ (p=0.011), CD4+ (p=0.015), CD8+ (p=0.048) and ratio CD4/CD8 (p=0.027), as well as with decreased IL2 (p=0.018), C4 (p=0.02), and IgG (p=0.05). IL2 and CD4+ counts were significant predictors of grade. CONCLUSIONS: A shift from Th1 to Th2, a CD3+ and CD19+ lymphocytopenia, a diminished fraction CD4/CD8 and a reduced amount of immunoglobulins and complement were observed in the patients with gliomas. A higher WHO grade of the tumor was associated with greater impairments of immunity. Since defects of both humoral and cellular immunity were equally observed and significant predictors of grade were assessed, a preoperative evaluation of the immune system of patients with gliomas is being proposed.
机译：目的：调查神经胶质瘤的细胞和体液免疫状况，以及它们与WHO分级系统的关系。材料与方法：我们进行了一项病例对照研究，研究了49例神经胶质瘤患者和30例健康对照。我们使用ELISA分析，放射免疫扩散，间接免疫荧光，乳胶测试和流式细胞术分析来评估术前血清中的免疫学特征。结果：胶质瘤患者的IL2（​​p = 0.000），TNF-a（p = 0.033），IgG（p = 0.011），IgA（p = 0.027），C4（p = 0.026），CD3 +（p与健康对照组相比，CD4 +（p = 0.000），CD4 +（p = 0.000），CD8 +（p = 0.002），CD4 / CD8（p = 0.000），CD19 +（p = 0.04）和IL10升高（p = 0.05）。关于病毒因子，总NK细胞，IgM，IgE，IL16，粒酶-b，RF，ANA，ENA，抗dsDNA和抗心磷脂抗体，未观察到统计学上的显着差异。在控制了年龄和性别之后，较高的WHO等级与CD3 +（p = 0.011），CD4 +（p = 0.015），CD8 +（p = 0.048）和CD4 / CD8比（p = 0.027）的数目减少相关。以及IL2（p = 0.018），C4（p = 0.02）和IgG（p = 0.05）降低。 IL2和CD4 +计数是等级的重要预测指标。结论：在脑胶质瘤患者中观察到了从Th1转变为Th2，CD3 +和CD19 +淋巴细胞减少，CD4 / CD8分数降低以及免疫球蛋白和补体的减少。较高的WHO WHO肿瘤分级与更大的免疫力损害相关。由于体液和细胞免疫缺陷均被观察到，并且评估了等级的重要预测因子，因此提出了术前评估神经胶质瘤患者免疫系统的方法。

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