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Regulatory T cells in myositis--Good Samaritans at the site of inflammation?

机译:肌炎中的调节性T细胞-炎症部位的好撒玛利亚人?

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摘要

Regulatory T cells (T_(regs)) are the main guardians against autoimmunity. Knowledge about these fundamentally important cells has literally exploded during the past years. Establishment and maintenance of self-tolerance is a complex process that includes both central (thymic) and peripheral check points (Jiang and Chess, 2006). Alterations in these critical steps of immunoregulation could induce suboptimal suppression of activated pathogenic immune cells eventually leading to autoimmunity (Venken et al., 2009). With the discovery of a specific subtype of CD4~+CD25~+ suppressor T cells, nowadays termed regulatory T cells or T_(regs), a major cellular component of immune regulation and dysregulation was identified (Sakaguchi et al., 1995).
机译:调节性T细胞(T_(regs))是抵抗自身免疫的主要监护人。在过去几年中,有关这些根本重要单元的知识激增了。建立和维持自我宽容是一个复杂的过程,包括中央(胸腺)检查点和周围检查点(Jiang和Chess,2006)。这些免疫调节关键步骤的改变可能会导致活化病原性免疫细胞的亚最佳抑制,最终导致自身免疫(Venken等,2009)。随着发现一种特定的亚型CD4〜+ CD25〜+抑制性T细胞,现今称为调节性T细胞或T_(regs),已确定了免疫调节和失调的主要细胞成分(Sakaguchi等,1995)。

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